Abstract
Anxiety and depression share genetic influences, and have been associated with similar cognitive biases. Psychological theories of anxiety and depression highlight threat interpretations of ambiguity. Little is known about whether genes influence cognitive style, or its links to symptoms. We assessed ambiguous word and scenario interpretations, anxiety and depression symptoms in 300 8-year-old twin pairs. There were significant correlations between both negative interpretations of ambiguous words and scenarios and depression symptoms after controlling for anxiety symptoms (r = .13 and .31, respectively), but no significant correlations with anxiety independent of depression. Genetic effects ranged from 16% for depression to 30% for ambiguous word interpretations. Non-shared environmental influences were large (68–70%). Both genetic and environmental influences contributed to the association between depression and ambiguous scenario interpretations. These findings support psychological theories, which emphasise the role of environmental stress both on the development of threat interpretations and on their links with symptoms. The data also support a role for genetic influence on threat interpretations, which may mediate responses to stress.
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Alfano, C. A., Beidel, D. C., & Turner, S. M. (2002). Cognition in childhood anxiety: conceptual, methodological, and developmental issues. Clinical Psychology Review, 22, 1209–1238.
Alloy, L. B., Abramson, L. Y., Whitehouse, W. G., Hogan, M. E., Tashman, N. A., Steinberg, D. L. et al. (1999). Depressogenic cognitive styles: predictive validity, information processing and personality characteristics, and developmental origins. Behaviour Research and Therapy, 37, 503–531.
Ambrose, B., & Rholes, W. S. (1993). Automatic cognitions and the symptoms of depression and anxiety in children and adolescents: An examination of the content-specificity hypothesis. Cognitive Therapy and Research, 17, 289–308.
Barrett, P. M., Rapee, R. M., Dadds, M. M., & Ryan, S. M. (1996). Family enhancement of cognitive style in anxious and aggressive children. Journal of Abnormal Child Psychology, 24, 187–203.
Beck, A. T. (1967). Depression: Causes and treatment. Philadelphia: Philadelphia University Press.
Beck, A. T., & Clark, D. A. (1988). Anxiety and depression: An information processing perspective. Anxiety Research, 1, 23–36.
Behar, L., & Stringfield, S. (1974). A behavior rating scale for the preschool child. Developmental Psychology, 33, 3–66.
Birmaher, B., Brent, D. A., Chiappetta, L., Bridge, J., Monga, S., & Baugher, M. (1999). Psychometric properties of the Screen for Child Anxiety Related Emotional Disorders (SCARED): a replication study. Journal of the American Academy of Child and Adolescent Psychiatry, 38, 1230–1236.
Bogels, S. M., & Zigterman, D. (2000). Dysfunctional cognitions in children with social phobia, separation anxiety disorder, and generalized anxiety disorder. Journal of Abnormal Child Psychology, 28, 205–211.
Butler, G., & Mathews, A. (1983). Cognitive processes in anxiety. Advances in Behaviour Research and Therapy, 5, 51–62.
Chorpita, B. F., & Barlow, D. H. (1998). The development of anxiety: The role of control in the early environment. Psychological Bulletin, 124, 3–21.
Cicchetti, D. (2005). Cognitive and affective neuroscience and developmental psychopathology. Development and Psychopathology, 17, 569–575.
Clark, D. A., Beck, A. T., & Alford, B. A. (1999). Scientific foundations of cognitive theory and therapy of depression. New York, NY: Wiley.
Clark, D. M., Salkovskis, P. M., Ost, L. G., Breitholtz, E., Koehler, K. A., Westling, B. E., et al. (1997). Misinterpretation of body sensations in panic disorder. Journal of Consulting and Clinical Psychology, 65, 203–213.
Creswell, C., Schniering, C. A., & Rapee, R. M. (2005). Threat interpretation in anxious children and their mothers: comparison with nonclinical children and the effects of treatment. Behaviour Research and Therapy, 43, 1375–1381.
Daleiden, E. L., & Vasey, M. W. (1997). An information-processing perspective on childhood anxiety. Clinical Psychology Review, 17, 407–429.
Dineen, K. A., & Hadwin, J. A. (2004). Anxious and depressive symptoms and children’s judgements of their own and others’ interpretation of ambiguous social scenarios. Journal of Anxiety Disorders, 18, 499–513.
Elander, J., & Rutter, M. (1996). Use and development of the Rutter parents’ and teachers’ scales. International Journal of Methods in Psychiatric Research, 6, 63–78.
Eley, T. C., Bolton, D., O’Connor, T. G., Perrin, S., Smith, P., & Plomin, R. (2003). A twin study of anxiety-related behaviours in pre-school children. Journal of Child Psychology and Psychiatry, 44, 945–960.
Eley, T. C., & Brown, T. A. (2004). Phenotypic and genetic/environmental structure of anxiety sensitivity in adolescents. Behavior Genetics, 34, 637.
Eley, T. C., & Stevenson, J. (1999a). Exploring the covariation between anxiety and depression symptoms: A genetic analysis of the effects of age and sex. Journal of Child Psychology and Psychiatry, 40, 1273–1284.
Eley, T. C., & Stevenson, J. (1999b). Using genetic analyses to clarify the distinction between depressive and anxious symptoms in children and adolescents. Journal of Abnormal Child Psychology, 27, 105–114.
French, C., C. & Richards, A. (1992). Word association norms for a set of threat/neutral homographs. Cognition and Emotion, 6, 65–87.
Fundudis, T., Berney, T. P., Kolvin, I., Famuyiwa, O. O., Barrett, M. L., Bhate, S. R., et al. (1991). Reliability and validity of two self-rating scales in the assessment of childhood depression. British Journal of Psychiatry, 159, 36–40.
Goodman, R., & Scott, S. (1999). Comparing the strengths and difficulties questionnaire and the Child Behavior Checklist: Is small beautiful? Journal of Abnormal Child Psychology, 27, 17–24.
Gregory, A. M., Caspi, A., Moffitt, T. E., Koenen, K., Eley, T. C., & Poulton, R. (2007b). Juvenile mental health histories of adults with anxiety disorders. American Journal of Psychiatry, 164, 301–308.
Gregory, A. M. & Eley, T. C. (2007). Genetic influences on anxiety in children: What we’ve learned and where we’re heading. Clinical Child and Family Psychology Review. DOI 10.1007/s10567-007-0022-8.
Gregory, A. M., Rijsdijk, F. V., Dahl, R. E., McGuffin, P., & Eley, T. C. (2006). Associations between sleep problems, anxiety and depression in twins aged 8 years. Pediatrics, 118, 1124–1132.
Gregory, A. M., Rijksdijk, F., Lau, J. Y. F., Napolitano, M., McGuffin, P., & Eley, T. C. (2007a). Interpersonal cognitions and associations with depressive symptoms in school-aged twins. Journal of Abnormal Psychology (in press).
Kovacs, M. (1985). The Children’s Depression Inventory (CDI). Psychopharmacology Bulletin, 21, 995–1124.
Lau, J. Y. F., & Eley, T. C. (2006). Changes in genetic and environmental influences on depressive symptoms across adolescence: A twin and sibling study. British Journal of Psychiatry, 189, 422–427 (in press).
Lau, J. Y. F., Rijsdijk, F. V., & Eley, T. C. (2006). I think, therefore I am: A twin study of attributional style in adolescents. Journal of Child Psychology and Psychiatry, 47, 696–703.
Little, R. J. A., & Rubin, D. B. (1987). Statistical analysis with missing data. New York: Wiley.
Martin, N., Boomsma, D. I., & Machin, G. (1997). A twin-pronged attack on complex trait. Nature Genetics, 17, 387–392.
Mathews, A., & MacLeod, C. (2002). Induced processing biases have causal effects on anxiety. Cognition and Emotion, 16, 331–354.
Monga, S., Birmaher, B., Chiappetta, L., Brent, D., Kaufman, J., Bridge, J., et al. (2000). Screen for Child Anxiety-Related Emotional Disorders (SCARED): convergent and divergent validity. Depression and Anxiety, 12, 85–91.
Neale, M. C., Boker, S. M., Xie, G., & Maes, H. M. (2002). Mx: Statistical Modeling (6th ed.). VCU Box 900126, Richmond, VA 23298: Department of Psychiatry.
Neale, M. C., & Cardon, L. R. (1992). Methodology for genetic studies of twins and families. Dordrecht: Kluwer.
Nunn, J. D., Mathews, A., & Trower, P. (1997). Selective processing of concern-related information in depression. British Journal of Clinical Psychology, 36, 489–503.
Plomin, R., Asbury, K., & Dunn, J. (2001). Why are children in the same family so different? Nonshared environment a decade later. Canadian Journal of Psychiatry, 46, 225–233.
Price, T. S., Freeman, B., Craig, I. W., Petrill, S. A., Ebersole, L., & Plomin, R. (2000). Infant zygosity can be assigned by parental report questionnaire data. Twin Research, 3, 129–133.
Rice, F., Harold, G., & Thaper, A. (2002). The genetic aetiology of childhood depression: A review. Journal of Child Psychology and Psychiatry and Allied Disciplines, 43, 65–80.
Rutter, M., Pickles, A., Murray, R., & Eaves, L. (2001). Testing hypotheses on specific environmental causal effects on behavior. Psychological Bulletin, 127, 291–324.
Stein, M. B., Jang, K. L., & Livesley, W. J. (1999). Heritability of anxiety sensitivity: A twin study. American Journal of Psychiatry, 156, 246–251.
Taghavi, M. R., Moradi, A. R., Neshat-Doost, H. T., Yule, W., & Dalgleish, T. (2000). Interpretation of ambiguous emotional information in clinically anxious children and adolescents. Cognition and Emotion, 14, 809–822.
Thapar, A., & McGuffin, P. (1994). A twin study of depressive symptoms in childhood. British Journal of Psychiatry, 165, 259–265.
Topolski, T. D., Hewitt, J. K., Eaves, L., Meyer, J. M., Silberg, J. L., Simonoff, E., et al. (1999). Genetic and environmental influences on ratings of manifest anxiety by parents and children. Journal of Anxiety Disorders, 13, 371–397.
Trouton, A., Spinath, F. M., & Plomin, R. (2002). Twins Early Development Study (TEDS): A multivariate, longitudinal genetic investigation of language, cognition and behaviour problems in childhood. Twin Research, 5, 444–448.
Williams, J. M. G., Watts, F. N., MacLeod, C., & Mathews, A. (1997). Cognitive psychology and emotional disorders (2nd ed.) Guilford: Wiley.
Acknowledgements
The ECHO study is funded by a Medical Research Council Career Development Award to the first author. The preparation of this manuscript was also supported by an ESRC fellowship to the second author. We thank the families who participated in this study, and Georgina Hosang, Fiona Mcleod, Robert Plomin and Jasmine Singh for their input.
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Eley, T.C., Gregory, A.M., Lau, J.Y.F. et al. In the Face of Uncertainty: A Twin Study of Ambiguous Information, Anxiety and Depression in Children. J Abnorm Child Psychol 36, 55–65 (2008). https://doi.org/10.1007/s10802-007-9159-7
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DOI: https://doi.org/10.1007/s10802-007-9159-7