Skip to main content

Advertisement

SpringerLink
Log in

Vitamin D mediates the association between acrylamide hemoglobin biomarkers and obesity

  • Research Article
  • Published:
Environmental Science and Pollution Research Aims and scope Submit manuscript

A Correction to this article was published on 08 November 2021

This article has been updated

Abstract

Mediation analysis aims to discover the role of intermediate variables from exposure to disease. The current study was performed to evaluate how vitamin D mediates the association between acrylamide hemoglobin biomarkers and obesity. Data were collected on 10,377 adults participating in the National Health and Nutrition Examination Survey (NHANES) 2003–2006 and 2013–2014 aged ≥ 18 years. Obesity was assessed through body mass index and abdominal circumference measurements. Generalized linear and restricted cubic spline (RCS) regression were used to estimate the association between vitamin D and acrylamide hemoglobin biomarkers, and the mediation effect of vitamin D was also discussed. After adjusting for potentially confounding factors, vitamin D had strong negative associations with serum concentrations of acrylamide hemoglobin adducts (HbAA, HbGA, and HbAA + HbGA). The RCS plots demonstrated that vitamin D was inversely and nonlinearly associated with HbAA and HbAA + HbGA while inversely and linearly associated with HbGA, and also a striking difference when vitamin D was lower than 60 nmol/L. Mediation analysis suggested that a negative correlation between acrylamide and obesity was mediated by vitamin D. The current study is expected to offer a fresh perspective on reducing the toxicity of acrylamide.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

Data availability

Not applicable.

Change history

References

  • Afshin A Forouzanfar, MH Reitsma, MB Sur, P Estep, K Lee A, et al (2017) Health effects of overweight and obesity in 195 countries over 25 years. GBD 2015 Obesity Collaborators. N Engl J Med 377(1):13–27

  • Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G (2016) Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects. Physiol Rev 96(1):365–408

    Article  CAS  Google Scholar 

  • Chu P-L, Lin L-Y, Chen P-C, Su T-C, Lin C-Y (2017) Negative association between acrylamide exposure and body composition in adults: NHANES, 2003–2004. Nutr Diabetes 7(3):e246

    Article  CAS  Google Scholar 

  • Chu P-L, Liu H-S, Wang C, Lin C-Y (2020) Association between acrylamide exposure and sex hormones in males: NHANES, 2003–2004. PLoS One 15(6):e0234622

  • Curtis T, Halford N (2016) Reducing the acrylamide-forming potential of wheat. Food Energy Secur 5:153–164

  • Daniel RM, De Stavola BL, Cousens SN, Vansteelandt S (2015) Causal mediation analysis with multiplemediators. Biometrics 71(1):1–14

    Article  CAS  Google Scholar 

  • Davuljigari CB, Ekuban FA, Zong C, Fergany AAM, Morikawa K, Ichihara G (2021) Nrf2 activation attenuates acrylamide-induced neuropathy in mice. Int J Mol Sci 22(11):5995

    Article  CAS  Google Scholar 

  • Duarte-Salles T, von Stedingk H, Granum B, Gützkow KB, Rydberg P et al (2013) Dietary acrylamide intake during pregnancy and fetal growth-results from the Norwegian mother and child cohort study (MoBa). Environ Health Perspect 121(3):374–379

    Article  Google Scholar 

  • Dzik KP, Kaczor JJ (2019) Mechanisms of vitamin D on skeletal muscle function: oxidative stress, energy metabolism and anabolic state. Eur J Appl Physiol 119(4):825–839

    Article  CAS  Google Scholar 

  • Erkekoglu P, Baydar T (2014) Acrylamide neurotoxicity. Nutr Neurosci 17:49–57

    Article  CAS  Google Scholar 

  • European Food Safety Authority (2009) Results on the monitoring of acrylamide levels in food. EFSA J 7: RN-285

  • Ghanayem BI, Bai Re, Kissling GE, Travlos G, Hoffler U (2010) Diet-induced obesity in male mice is associated with reduced fertility and potentiation of acrylamide-induced reproductive toxicity. Biol Reprod 82(1):96–104

    Article  CAS  Google Scholar 

  • Ghosh S, Bouchard C (2017) Convergence between biological, behavioural and genetic determinants of obesity. Nat Rev Genet 18(12):731–748

    Article  CAS  Google Scholar 

  • Grant WB, Cross HS, Garland CF, Gorham ED, Moan J, Peterlik M, Porojnicu AC, Reichrath J, Zittermann A (2009) Estimated benefit of increased vitamin D status in reducing the economic burden of disease in western Europe. Prog Biophys Mol Biol 99(2–3):104–13

    Article  CAS  Google Scholar 

  • Gonzalez FJ (2005) Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1. Mutat Res 569:101–110

    Article  CAS  Google Scholar 

  • Hogervorst J, Vesper HW, Madhloum N, Gyselaers W, Nawrot T (2021) Cord blood acrylamide levels and birth size, and interactions with genetic variants in acrylamide-metabolising genes. Environ Health 20:35

    Article  CAS  Google Scholar 

  • Hsu C-N, Hou C-Y, Pei-Chen Lu, Chang-Chien G-P, Lin S, Tain Y-L (2020) Association between acrylamide metabolites and cardiovascular risk in children with early stages of chronic kidney disease. Int J Mol Sci 21(16):5855

    Article  CAS  Google Scholar 

  • IARC (1994) Some Industrial Chemicals IARC monographs on evaluation of carcinogenic risks to humans. Volume 60. World Health Organization, International Agency for Research on Cancer; Lyon, 1994. Acrylamide, pp 389–433

  • Ingrid LD, Nenseth CB, Bere E, Bjørnarå HBT, Helland SH, Øverby NC et al (2017) The association between time scarcity, sociodemographic correlates and consumption of ultra-processed foods among parents in Norway: a cross-sectional study. BMC Public Health 17:447

  • JECFA 2011 Evaluation of Certain Food Additives and Contaminants. 72nd Report of the Joint FAO/Who Expert Committee on Food Additive. WHO Press, Geneva

  • Jiang G, Zhang L, Wang H, Chen Q, Wu X, Yan X, Chen Y, Xie M (2018) Protective effects of a Ganoderma atrum polysaccharide against acrylamide induced oxidative damage via a mitochondria mediated intrinsic apoptotic pathway in IEC-6 cells. Food Funct 9(2):1133–1143

    Article  CAS  Google Scholar 

  • Jones G, Prosser DE, Kaufmann M (2014) Cytochrome P450-mediated metabolism of vitamin D. J. Lipid Res 55(1):13–31

    Article  CAS  Google Scholar 

  • Lee GH, Oh KJ, Kim HR, Han HS, Lee HY, Park KG et al (2016) Effect of BI-1 on insulin resistance through regulation of CYP2E1. Sci Rep. 6:32229

    Article  CAS  Google Scholar 

  • Lin CY, Lee HL, Chen YC, Lien GW, Lin LY, Wen LL et al (2013) Positive association between urinary levels of 8-hydroxydeoxyguanosine and the acrylamide metabolite N-acetyl-S-(propionamide)-cysteine in adolescents and young adults. J Haz Mat 261:372–377

    Article  CAS  Google Scholar 

  • Lin CY, Lin LY, Chen YC, Wen LL, Chien KL, Sung FC et al (2015) Association between measurements of thyroid function and the acrylamide metabolite N-Acetyl-S-(propionamide)-cysteine in adolescents and young adults. Environ Res 136:246–252

    Article  CAS  Google Scholar 

  • Lin CY, Lin YC, Kuo HK, Hwang JJ, Lin JL, Chen PC et al (2009) Association among acrylamide, blood insulin, and insulin resistance in adults. Diabetes Care 32:2206–2211

    Article  CAS  Google Scholar 

  • Linhart K, Bartsch H, Seitz HK (2014) The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts. Redox Biol 3:56–62

    Article  CAS  Google Scholar 

  • Ma Q, Cai S, Jia Y, Sun X, Yi Junjie, Jiang D (2020) Effects of Hot-Water Extract from Vine Tea (Ampelopsis grossedentata) on Acrylamide Formation, Quality and Consumer Acceptability of Bread. Foods 9(3):373

    Article  CAS  Google Scholar 

  • Meyerhardt JA, Niedzwiecki D, Hollis D, Saltz LB, Mayer RJ, Nelson H, el at, (2008) Impact of body mass index and weight change after treatment on cancer recurrence and survival in patients with stage III colon cancer: findings from Cancer and Leukemia Group B 89803. J Clin Oncol 26:4109–4115

    Article  Google Scholar 

  • Miśkiewicz K, Nebesny E, Rosicka-Kaczmarek J, Żyżelewicz D, Budryn G (2018) The effects of baking conditions on acrylamide content in shortcrust cookies with added freeze-dried aqueous rosemary extract. J Food Sci Technol 55(10):4184–4196

    Article  Google Scholar 

  • Mojska H, Gielecińska I, Jasińska-Melon E, Winiarek J, Sawicki W (2020) Are AAMA and GAMA levels in urine after childbirth a suitable marker to assess exposure to acrylamide from passive smoking during pregnancy?—a pilot study. Int J Environ Res Public Health 17(20):7391

    Article  CAS  Google Scholar 

  • Mogire RM, Mutua A, Kimita W, Kamau A, Bejon P, Pettifor JM, el at, (2020) Prevalence of vitamin D deficiency in Africa: a systematic review and meta-analysis. Lancet Glob Health 8(1):e134–e142

    Article  Google Scholar 

  • Mottram DS, Wedzicha BL, Dodson AT (2002) Acrylamide is formed in the Maillard reaction. Nature 419(6906):448–449

    Article  CAS  Google Scholar 

  • Mucci LA, Wilson KM (2008) Acrylamide intake through diet and human cancer risk. J Agric Food Chem 56(15):6013–6019

    Article  CAS  Google Scholar 

  • Norman RE, Carpenter DO, Scott J, Brune MN, Sly PD (2013) Environmental exposures: an underrecognized contribution to noncommunicable diseases. Rev Environ Health 28(1):59–65

    Article  CAS  Google Scholar 

  • Nowak A, Zakłos-Szyda M, Żyżelewicz D, Koszucka A, Motyl I (2020) Acrylamide decreases cell viability, and provides oxidative stress, DNA damage, and apoptosis in human colon adenocarcinoma cell line Caco-2. Molecules 25(2):368

    Article  CAS  Google Scholar 

  • Palus K, Bulc M, Całka J (2020) Effect of acrylamide supplementation on the population of vasoactive intestinal peptide (VIP)-like immunoreactive neurons in the porcine small intestine. Int J Mol Sci 21(24):9691

    Article  CAS  Google Scholar 

  • Regnier SM, Sargis RM (2014) Adipocytes under assault: environmental disruption of adipose physiology. Biochim Biophys Acta 1842(3):520–533

    Article  CAS  Google Scholar 

  • Roberto CA, Swinburn B, Hawkes C, Huang TT, Costa SA, Ashe M et al (2015) Patchy progress on obesity prevention: emerging examples, entrenched barriers, and new thinking. Lancet 385(9985):2400–2409

    Article  Google Scholar 

  • Rifai L, Saleh Fatima A (2020) A Review on Acrylamide in Food: Occurrence, Toxicity, and Mitigation Strategies. Int J Toxicol 39(2):93–102

    Article  CAS  Google Scholar 

  • Risk Factor Collaborators (2017) Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. GBD 2017. Lancet. 2018 392(10159):1923–1994.

  • Sarocka A, Kovacova V, Omelka R, Grosskopf B, Kapusta E, Goc Z et al (2019) Single and simultaneous effects of acrylamide and ethanol on bone microstructure of mice after one remodeling cycle. BMC Pharmacol Toxicol 20:38

    Article  Google Scholar 

  • Sievert K, Lawrence M, Naika A, Baker P (2019) Processed foods and nutrition transition in the pacific: regional trends, patterns and food system drivers. Nutrients 11(6):1328

    Article  CAS  Google Scholar 

  • Vanderweele TJ, Vansteelandt S (2010) Odds ratios for mediation analysis for a dichotomous outcome. Am J Epidemiol 172(12):1339–1348

    Article  Google Scholar 

  • Wolk R, Somers VK (2006) Obesity-related cardiovascular disease: implications of obstructive sleep apnea. Diabetes Obes Metab 8:250–260

    Article  CAS  Google Scholar 

  • Wang RS, McDaniel LP, Manjanatha MG, Shelton SD, Doerge DR, Mei N (2010) Mutagenicity of acrylamide and glycidamide in the testes of big bluemice. Toxicol Sci 117:72–80

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank all the participants in the CDC for conducting the NHANES survey and NCHS staff for providing us with consultation on the application of survey weights.

Funding

This work was supported by a National Science Foundation grant (Grant No.81770396).

Author information

Author notes

  1. Ting Yin, Fang Xu, Shi Shi contributed equally to this work.

Authors and Affiliations

  1. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China

    Ting Yin, Fang Xu, Shi Shi, Shengen Liao, Haifeng Zhang, Yanli Zhou & Xinli Li

  2. Gusu School, Nanjing Medical University, Suzhou, 215002, China

    Haifeng Zhang

  3. Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, 215002, China

    Haifeng Zhang

  4. Jiangxi Environmental Engineering Vocational College, Zhangong district, Ganzhou city, Jiangxi, 341000, China

    Xiaosu Tang

Authors
  1. Ting Yin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Fang Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shi Shi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shengen Liao
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Xiaosu Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Haifeng Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yanli Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Xinli Li
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

TY and FX designed and conceived the study proposal and drafted the manuscript; SS and SL conducted statistical analyses and analyzed the data; XT was responsible for supervision and software; YZ and HZ studied the literature; YZ and XL led the design of the study and revised the manuscript. All authors have read and approved the final manuscript.

Corresponding authors

Correspondence to Yanli Zhou or Xinli Li.

Ethics declarations

Ethics approval and consent to participate

The CDC/NCHS Ethics Review Board approved the NHANES study and gave approval for public dissemination. The consent form was signed by all participants in the survey, and participants consented to store specimens of their blood for future research.

Consent for publication

Not applicable. There is no individual-level data in our publication.

Competing interests

The authors declare no competing interests.

Additional information

Responsible editor: Ludek Blaha.

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

The original online version of this article was revised: The statement for the equal contribution of the Authors is corrected in the original published proof.

Highlights

• Reconfirmed the negative correlation between acrylamide and obesity in a large sample representative population in the USA.

• First put forward the impacts of vitamin D to mediate the associations between acrylamide and obesity.

• Exposure to acrylamide is nonlinearly and inversely associated with vitamin D, and there is a striking difference when vitamin D is lower than 60 nmol/L.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yin, T., Xu, F., Shi, S. et al. Vitamin D mediates the association between acrylamide hemoglobin biomarkers and obesity. Environ Sci Pollut Res 29, 17162–17172 (2022). https://doi.org/10.1007/s11356-021-16798-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11356-021-16798-8

Keywords

Search

Navigation