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Association between hemoglobin adducts of ethylene oxide levels and the risk of short sleep duration in the general population: an analysis based on the National Health and Nutrition Examination Survey

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Abstract

This study aimed to evaluate the association between blood ethylene oxide (HbEtO) levels and short sleep duration (SSD). Data of 3438 participants aged 20 years or older in this study were collected from the National Health and Nutrition Examination Survey (NHANES). The ethylene oxide (EtO) biomarker (HbEtO) was quantified in blood using a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method. SSD was defined as sleep time equal to or less than 6 h. The analyses utilized weighted logistic regression models and restricted cubic spline. There was a significant non-linear relationship between HbEtO levels and the risk of SSD (P for-nonlinearity = 0.035). After the full adjustment for confounders, compared with the lowest quantile, the odds ratios (ORs) with 95% confidence intervals (CIs) of SSD across the quantiles of ethylene oxide levels were 1.54(1.09–2.18), 1.15(0.87–1.53), and 1.80(1.11–2.92), respectively (P for trend < 0.05). In subgroup analysis, people who were female, who were non-Hispanic Black, who never engaged in physical activity, who consumed alcohol ≤ 14 g/day, who were normal weight or obese had a significantly higher risk of SSD when they had highest quartiles of HbEtO levels than those had lowest (p < 0.05). Our study indicated that HbEtO levels, an indicator for EtO exposure, were associated with SSD in general adult populations.

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Availability of data and materials

The data utilized to support the findings are available from the corresponding authors upon request.

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Funding

This work was supported by the Natural Science Basic Research Program of Shaanxi (2020JQ-952). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Authors and Affiliations

  1. Department of Gynecologic Oncology, Shaanxi Provincial Cancer Hospital, 710061, Xi’an, China

    Lu Han & Qi Wang

  2. Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi’an Jiaotong University, 710061, Xi’an, China

    Lu Han & Qi Wang

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  1. Lu Han
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Contributions

LH conceived and designed the study. QW extracted and analyzed data. LH and QW wrote the manuscript. All authors reviewed and approved the final manuscript.

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Correspondence to Qi Wang.

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All data used in this study were accessed from NHANES, a continuous program performed by the National Center for Health Statistics.

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Responsible Editor: Lotfi Aleya

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Han, L., Wang, Q. Association between hemoglobin adducts of ethylene oxide levels and the risk of short sleep duration in the general population: an analysis based on the National Health and Nutrition Examination Survey. Environ Sci Pollut Res 30, 76761–76768 (2023). https://doi.org/10.1007/s11356-023-27734-3

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