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Galectin-1 receptors in different cell types

  • Published:
Journal of Biomedical Science

Summary

Galectins are a family of animal lectins defined by two properties: shared amino acid sequences in their carbohydrate-recognizing domain, and β-galactoside affinity. A wide variety of biological phenomena are related to galectins, i.e., development, differentiation, morphogenesis, tumor metastasis, apoptosis, RNA splicing, and immunoregulatory function. In this review, we will focus on galectin-1 receptors, and some of the mechanisms by which this lectin affects different cell types. Several galectin-1 receptors are discussed such as CD45, CD7, CD43, CD2, CD3, CD4, CD107, CEA, actin, extracellular matrix proteins such as laminin and fibronectin, glycosaminoglycans, integrins, a β-lactosamine glycolipid, GM1 ganglioside, polypeptide HBGp82, glycoprotein 90 K/MAC-2BP, CA125 cancer antigen, and pre-B cell receptor.

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Abbreviations

CA125 :

cancer antigen CA125

CD :

circular dichroism

CEA:

carcinoembryonic antigen

CHO:

Chinese hamster ovary

C2GnT:

core 2 β-1,6-N-acetylglucosaminyltransferase

CRD:

carbohydrate-recognizing domain

CR3:

complement receptor 3

ECM:

extracellular matrix

ER:

endoplasmic reticulum

ERK:

extracellular signal-regulated kinase

GAG:

glycosaminoglycans

GM1:

GM1 ganglioside

GNTV:

β-1,6-N-acetylglucosaminyl-transferase V

HBGp82:

human brain galectin-1-binding polypeptide of 82 kD

hsp:

heat shock protein

90 K/MAC-2BP :

glycoprotein of 90 kD or Mac-2-binding protein

LacNAc:

N-acetyl-lactosamine

LAMP-1/2:

lysosome-associated membrane proteins 1/2

LNnT:

lacto-N-neotetraosyl ceramide

mAb:

monoclonal antibody

MAPK:

mitogen-activated protein kinase

MEK:

mitogen-activated protein kinase kinase

MEKK:

mitogen-activated protein kinase kinase kinase

MW:

molecular weight

NMR:

nuclear magnetic resonance

PL:

poly-N-acetyl-lactosamine

pre-BCR:

pre-B cell receptor

PTP:

protein tyrosine phosphatase

RCA:

Ricinus communis agglutinin

SLC:

surrogate light chain

SMC:

smooth muscle cells

SNA:

Sambucus nigra agglutinin

ST6Gal I:

sialyltransferase specific for SAα2,6Gal

TCR:

T cell receptor

TDG:

thiodigalactoside.

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Authors and Affiliations

  1. Fundación Instituto Leloir, Instituto de Investigaciones Bioquímicas de Buenos Aires, Patricias Argentinas, 435 (1405), Buenos Aires, Argentina

    María T. Elola & José Mordoh

  2. Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y, 115 (1900), La Plata, Argentina

    María E. Chiesa, Alejandra Fernández Alberti & Nilda E. Fink

Authors
  1. María T. Elola
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  2. María E. Chiesa
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  3. Alejandra Fernández Alberti
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  4. José Mordoh
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Correspondence to María T. Elola.

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Elola, M.T., Chiesa, M.E., Alberti, A.F. et al. Galectin-1 receptors in different cell types. J Biomed Sci 12, 13–29 (2005). https://doi.org/10.1007/s11373-004-8169-5

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