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The regulation effect of AMPK in immune related diseases

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Abstract

AMP-activated protein kinase (AMPK) is a sensor of cellular energy status that plays a key role in energetic metabolism regulation. Metabolic changes in immune cells, such as dendritic cell (DC), macrophages, neutrophils and lymphocytes that participate in the signal directed programs that promote or inhibit immune mediated diseases, including cancer, atherosclerosis and inflammatory diseases. Multiple pathogenic mechanisms are involved in the initiation and progression of disease, and many pathways have been uncovered. The mechanistic overlap in the metabolic changes and inflammation could indicate that some of the targets they have are in common, whereas AMPK could be useful in treatment of both disorders. The insight into identification of AMPK responsible for specific immune regulation, anti-inflammatory actions and understanding of the underlying molecular mechanism will promote the generation of novel AMPK activators, and provide novel therapy strategy.

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Acknowledgements

This work was supported by the Science and Technology Innovation Team of Shanxi Province (201605D131045-18) and Key Laboratory of Effective Substances Research and Utilization in Traditional Chinese Medicine of Shanxi Province (201605D111004).

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Authors and Affiliations

  1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, 030006, China

    Jing Wang, Zhenyu Li, Li Gao, Yanshuang Qi & Xuemei Qin

  2. State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China

    Haibo Zhu

  3. Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China

    Haibo Zhu

  4. Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China

    Haibo Zhu

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  1. Jing Wang
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  2. Zhenyu Li
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  3. Li Gao
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  4. Yanshuang Qi
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  5. Haibo Zhu
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Correspondence to Haibo Zhu or Xuemei Qin.

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Wang, J., Li, Z., Gao, L. et al. The regulation effect of AMPK in immune related diseases. Sci. China Life Sci. 61, 523–533 (2018). https://doi.org/10.1007/s11427-017-9169-6

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