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Remineralization of initial enamel caries in vitro using a novel peptide based on amelogenin

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Abstract

Dental caries is the most common oral disease with high incidence, widely spread and can seriously affect the health of oral cavity and the whole body. Current caries prevention measures such as fluoride treatment, antimicrobial agents, and traditional Chinese herbal, have limitations to some extent. Here we design and synthesize a novel peptide based on the amelogenin, and assess its ability to promote the remineralization of initial enamel caries lesions. We used enamel blocks to form initial lesions, and then subjected to 12-day pH cycling in the presence of peptide, NaF and HEPES buffer. Enamel treated with peptide or NaF had shallower, narrower lesions, thicker remineralized surfaces and less mineral loss than enamel treated with HEPES. This peptide can promote the remineralization of initial enamel caries and inhibit the progress of caries. It is a promising anti-caries agent with various research prospects and practical application value.

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Authors and Affiliations

  1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China

    Danxue Li, Xueping Lv, Huanxin Tu, Xuedong Zhou, Haiyang Yu & Linglin Zhang

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  1. Danxue Li
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  2. Xueping Lv
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  3. Huanxin Tu
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  4. Xuedong Zhou
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  5. Haiyang Yu
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  6. Linglin Zhang
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Correspondence to Linglin Zhang.

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Li, D., Lv, X., Tu, H. et al. Remineralization of initial enamel caries in vitro using a novel peptide based on amelogenin. Front. Mater. Sci. 9, 293–302 (2015). https://doi.org/10.1007/s11706-015-0298-4

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  • DOI: https://doi.org/10.1007/s11706-015-0298-4

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