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Synthesis of pH-responsive triazine skeleton nano-polymer composite containing AIE group for drug delivery

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Abstract

We exploited a unique porous structure of the nano-covalent triazine polymer (NCTP) containing aggregation-induced emission (AIE) group to achieve controlled release and drug tracking in tumor acidic microenvironment. NCTP was synthesized by the Friedel-Crafts alkylation and the McMurry coupling reaction. It not only had strong doxorubicin (DOX)-loading capacity due to its high specific surface area and large pore volume, but also showed the significant cumulative drug release as a result of the pH response of triazine polymers. NCTP was induced luminescence after mass accumulation near tumor cells. Besides, it had excellent biocompatibility and obvious antineoplastic toxicity. The results demonstrate that NCTP as a utility-type drug carrier provides a new route for designing the multi-functional drug delivery platform.

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Acknowledgements

This work was supported by the Corps Division Development and Innovation Support Program (2017BA041), the National Natural Science Foundation of China (Grant Nos. 21866028 and 51662036), the Engineering Research Center of Materials-Oriented Chemical Engineering of Xinjiang Bintuan (2016BTRC008 and 2016BTRC005) and the Natural Science Foundation of Shihezi University (ZZZC201922A).

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Author notes

  1. Y.Z. and X.P. contributed equally to this work.

Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Shihezi University/Key Laboratory of Green Process for Chemical Engineering/Key Laboratory for Chemical Materials of Xinjiang Uygur Autonomous Region/Engineering Center for Chemical Materials of Xinjiang Bingtuan, Shihezi University, Shihezi, 832003, China

    Yifan Zhang, Xueying Peng, Xinbo Jing, Shengchao Yang, Jianning Wu, Guihua Meng, Zhiyong Liu & Xuhong Guo

  2. School of Medicine, Shihezi University, Shihezi, 832003, China

    Lin Cui

  3. State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai, 200237, China

    Xuhong Guo

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  1. Yifan Zhang
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  2. Xueying Peng
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  3. Xinbo Jing
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  4. Lin Cui
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Correspondence to Lin Cui or Zhiyong Liu.

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Zhang, Y., Peng, X., Jing, X. et al. Synthesis of pH-responsive triazine skeleton nano-polymer composite containing AIE group for drug delivery. Front. Mater. Sci. 15, 113–123 (2021). https://doi.org/10.1007/s11706-021-0539-7

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  • DOI: https://doi.org/10.1007/s11706-021-0539-7

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