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Association of ACYP2 and TSPYL6 Genetic Polymorphisms with Risk of Ischemic Stroke in Han Chinese Population

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Abstract

The development of ischemic stroke is associated with advanced age. Telomere length, as a marker of biological aging, has been reported to influence the risk of several age-related diseases, including ischemic stroke. Recent studies have identified the genetic variant within ACYP2 and TSPYL6 associated with shorter telomere length. The objective of this study is to investigate the putative association of ischemic stroke with common polymorphisms in ACYP2 and TSPYL6 genes in a Chinese Han population. We found that the risk alleles of six single nucleotide polymorphisms (SNPs), including rs11125529, rs12615793, rs843711, rs11896604, and rs843706 within both ACYP2 and TSPYL6, and rs17045754 in ACYP2 gene, were related with increased risk of ischemic stroke according to both allelic and genotype association analyses. The significant correlations between ACYP2 and TSPYL6 SNPs and ischemic stroke risk were also observed in dominant, recessive, and additive models, respectively. Two blocks in high linkage disequilibrium were identified in this study, and two haplotypes were associated with higher ischemic stroke susceptibility. In conclusion, the genetic polymorphisms of ACYP2 and TSPYL6 are associated with increased risk of developing ischemic stroke. Further studies with larger sample sizes are required to validate our findings.

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Acknowledgments

This work is supported by the Special Foundation for Public Health of Ministry of Health of China (No. 201002011). The authors are grateful to the scientists and staff from Northwest University for assistance in SNP genotyping.

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    Authors and Affiliations

    1. Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of China

      Yiqian Liang, Rui Zhang, Shuo Zhang, Guofa Ji, Puyu Shi, Tian Yang, Feng Liu, Jing Feng & Mingwei Chen

    2. Shaanxi Provincial Research Center for the Project of Prevention and Treatment of Respiratory Diseases, Xi’an, 710021, People’s Republic of China

      Yiqian Liang & Mingwei Chen

    3. Department of Respiratory Medicine, Hospital of Lantian County, Xi’an, 710500, People’s Republic of China

      Rui Zhang

    4. Department of Respiratory Medicine, Xi’an 141 Hospital, Xi’an, 710089, People’s Republic of China

      Guofa Ji

    5. Department of Internal Medicine, Xi’an International Studies University Hospital, Xi’an, 710061, People’s Republic of China

      Chunqi Li

    6. Department of Internal Medicine, Shaanxi Normal University Hospital, Xi’an, 710062, People’s Republic of China

      Dangshe Guo

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    1. Yiqian Liang
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    Yiqian Liang and Rui Zhang contributed equally to this work.

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    Liang, Y., Zhang, R., Zhang, S. et al. Association of ACYP2 and TSPYL6 Genetic Polymorphisms with Risk of Ischemic Stroke in Han Chinese Population. Mol Neurobiol 54, 5988–5995 (2017). https://doi.org/10.1007/s12035-016-0086-x

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