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P1 peptidase – a mysterious protein of family Potyviridae

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Abstract

The Potyviridae family, named after its type member, Potato virus Y (PVY), is the largest of the 65 plant virus groups and families currently recognized. The coding region for P1 peptidase is located at the very beginning of the viral genome of the family Potyviridae. Until recently P1 was thought of as serine peptidase with RNA-binding activity and with possible influence in cell-to-cell viral spreading. This N-terminal protein, among all of the potyviruses, is the most divergent protein: varying in length and in its amino acid sequence. Nevertheless, P1 peptidase in many ways is still a mysterious viral protein. In this review, we would like to offer a comprehensive overview, discussing the proteomic, biochemical and phylogenetic views of the P1 protein.

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Abbreviations

BCMNV:

Bean common mosaic necrosis virus

CI:

cylindrical inclusion

CMV:

Cucumber mosaic virus

CVYV:

Cucumber vein yellowing virus

HC-Pro:

helper component proteinase

MP:

movement protein

NIa:

nuclear inclusion-a peptidase

NBRF:

National Biomedical Research Foundation

PPV:

Plum pox virus

PSbMV:

Pea seed-borne mosaic virus

PVA:

Potato virus A

PVV:

Potato virus V

PVX:

Potato virus X

PVY:

Potato virus Y

SMV:

Soybean mosaic virus

TEV:

Tobacco etch virus

TuMV:

Turnip mosaic virus

TVMV:

Tobacco vein mottling virus

WMV:

Watermelon mosaic virus

YMV:

Yam mosaic virus

YTHS:

yeast two-hybrid system

ZYMV:

Zucchini yellow mosaic virus

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Acknowledgements

This work was supported by grant MSM 6198959215 (Ministry of Education, Youth and Sports of the Czech Republic). The excellent critical review by Juan Antonio Garcia Alvarez is gratefully acknowledged. We thank Peter Lemkin for editing the manuscript.

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  1. Faculty of Science, Palacký University in Olomouc, Šlechtitelů 11, 783 71, Olomouc-Holice, Czech Republic

    Jana Rohožková & Milan Navrátil

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  1. Jana Rohožková
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Correspondence to Jana Rohožková.

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Corresponding editor: Indranil Dasgupta

[Rohožková J and Navrátil M 2011 P1 peptidase–a mysterious protein of family Potyviridae. J. Biosci. 36 189–200] DOI 10.1007/s12038-011-9020-6

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Rohožková, J., Navrátil, M. P1 peptidase – a mysterious protein of family Potyviridae. J Biosci 36, 189–200 (2011). https://doi.org/10.1007/s12038-011-9020-6

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