Abstract
In this study, clove essential oil was used as a green antibacterial agent. Its nanoemulsion dosage form with particle size 217.7 ± 11.45 nm and PDI 0.66 ± 0.09 was first prepared. By adding carbomer 940, nanoemulsion was then transformed into the nanogel (NGel) to improve the essential oil’s activity and stability. Electrospun nanofibers of polyvinyl alcohol (PVANFs) with a mean diameter of 216 ± 14 nm were then prepared. The required characterizations such as ATR-FTIR spectroscopy, SEM image, and water contact angle were carried out. To easy usage topically, the NGel was impregnated on the PVANFs mat (NGelNFs). Interestingly, the prepared fast-degradable NGelNFs could inhibit (100%) the growth of four important pathogens, including Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumonia. Besides, the dressing was degraded after minutes of usage. The prepared GelNFs could be used as a capable and fast-degradable antibacterial substrate.
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Fasa University of Medical Sciences supported this work (Grant No. 97090). Also, this research has been ethically approved, IR.FUMS.REC.1397.152.
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Research Involving Humans and Animals Statement
This research did not include human and in vivo studies, and all experiments were performed in in vitro condition. After preparing the study’s final prototype only to observe the degradation of that on the human skin, it was applied to the corresponding author’s hand. This observation was vital for the design of subsequent studies.
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Zarenezhad, E., Abdollahi, A., Esmaeili, F. et al. A Fast-Degradable Nano-dressing with Potent Antibacterial Effect. BioNanoSci. 10, 983–990 (2020). https://doi.org/10.1007/s12668-020-00790-6
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DOI: https://doi.org/10.1007/s12668-020-00790-6