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Oxidative stress in relation to telomere length maintenance in vascular smooth muscle cells following balloon angioplasty

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Abstract

Telomeres are specialized DNA–protein complexes found at the tips of linear chromosomes. In this study, we investigated the effects of oxidative stress on telomeric length distribution of proliferating vascular smooth muscle cells following balloon injury in single or combined treatment of rabbits with either buthionine sulfoximine or taurine. Exposure to oxidative stress increased the balloon injury whereas taurine treatment significantly diminished l-buthionine-sulfoximine-related intimal hyperplasia. Our results also showed that both variables had a significant influence on mean telomeric length distribution.

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Acknowledgement

Our research was supported by grants from The Scientific and Technological Research Council of Turkey (SBAG-K-70, ZK) and Ege University Research Found (04ECZ012, GOS). This study was part of a Ph.D. thesis submitted to the Institute of Health Sciences of Ege University, Izmir, Turkey, by Ozsarlak-Sozer.

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Authors and Affiliations

  1. Department of Pharmacology, Ege University, 35100, Izmir, Turkey

    Gonen Ozsarlak-Sozer, Zeliha Kerry & Goksel Gokce

  2. Department of Radiology, Faculty of Medicine, Ege University, 35100, Izmir, Turkey

    Ismail Oran

  3. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Ege University, 35100, Izmir, Turkey

    Zeki Topcu

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  1. Gonen Ozsarlak-Sozer
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  2. Zeliha Kerry
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  3. Goksel Gokce
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  4. Ismail Oran
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  5. Zeki Topcu
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Correspondence to Zeki Topcu.

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Ozsarlak-Sozer, G., Kerry, Z., Gokce, G. et al. Oxidative stress in relation to telomere length maintenance in vascular smooth muscle cells following balloon angioplasty. J Physiol Biochem 67, 35–42 (2011). https://doi.org/10.1007/s13105-010-0046-2

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  • DOI: https://doi.org/10.1007/s13105-010-0046-2

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