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Resistance training status modifies inflammatory response to explosive and hypertrophic resistance exercise bouts

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Abstract

The purpose of the present study was to examine the immediate and prolonged immune response in circulating cytokine and adipocytokine concentrations after two different resistance exercise bouts: hypertrophic (HYP1, 5 × 10, 80% of 1RM) and maximal explosive (POW1, 10 × 5, 60% of 1RM) resistance exercise bouts and how 12 weeks of resistance training (RT) modifies these responses (HYP2, POW2). Eight men completed the study. RE-induced interleukin-6 (IL-6), interleukin-1β (IL-1β), interleukin-1 receptor antagonist (IL-1ra), monocyte-chemoattractant protein-1 (MCP-1), leptin, resistin, and adiponectin were measured before (PRE) and immediately (POST0), 24 (POST24) and 48 (POST48) hours after RE bouts before and after RT. In the untrained state, IL-6 increased immediately after RE in HYP1 (p = 0.002) and in POW1 (p = 0.003) whereas no changes were observed after RT. Similar results were observed in IL-1β, whereas conversely, IL-1ra increased only after RT in HYP2 and POW2 (p < 0.05). Resistin increased before RT in HYP1 and in POW1 (p = 0.011 and p = 0.003, respectively), but after RT, significant responses were not observed. Interestingly, in HYP2, MCP-1 increased significantly at POST24 (p = 0.009) and at POST48 (p = 0.032) only following RT. The present study shows that RT modifies RE-induced cytokine responses towards an anti-inflammatory direction.

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Acknowledgements

This work was supported by Tekes-National Technology Agency of Finland with University of Jyväskylä (Decision No. 70007/13), Juho Vainion Foundation, Jenny and Antti Wihuri Foundation, Yrjö Jahnsson foundation, the Department of Biology of Physical Activity, University of Jyväskylä, and the competitive research funding of Pirkanmaa Hospital District. The authors would like to thank the subjects and research assistants. For ELISA analyses, the excellent technical assistance of Terhi Salonen and Salla Hietakangas is warmly acknowledged.

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Authors and Affiliations

  1. Biology of Physical Activity, Faculty of Sport and Health Sciences, University of Jyväskylä, P.O Box 35, 40014, Jyväskylä, Finland

    Johanna K. Ihalainen, Juha P. Ahtiainen, Simon Walker, Heikki Peltonen & Antti A. Mero

  2. The Norwegian Olympic and Paralympic Committee and Confederation of Sports, Oslo, Norway

    Gøran Paulsen

  3. Norwegian School of Sport Sciences, Oslo, Norway

    Gøran Paulsen

  4. Department of Psychology, University of Jyväskylä, Jyväskylä, Finland

    Harri Selänne

  5. The Immunopharmacology Research Group, Faculty of Medicine and Life Sciences, University of Tampere and Tampere University Hospital, Tampere, Finland

    Mari Hämäläinen & Eeva Moilanen

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  1. Johanna K. Ihalainen
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  2. Juha P. Ahtiainen
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  3. Simon Walker
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Correspondence to Johanna K. Ihalainen.

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The study was conducted according to the Declaration of Helsinki, and ethical approval for the study procedures was granted by the Ethical Committee at the University of Jyväskylä and by the Ethical Committee of the Central Hospital, Jyväskylä.

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Ihalainen, J.K., Ahtiainen, J.P., Walker, S. et al. Resistance training status modifies inflammatory response to explosive and hypertrophic resistance exercise bouts. J Physiol Biochem 73, 595–604 (2017). https://doi.org/10.1007/s13105-017-0590-0

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