Abstract
The therapeutic effects of antioxidant-loaded nanoemulsion can be often optimized by controlling the release rate in human body. Release kinetic models can be used to predict the release profile of antioxidant compounds and allow identification of key parameters that affect the release rate. It is known that one of the critical aspects in establishing a reliable release kinetic model is to understand the underlying release mechanisms. Presently, the underlying release mechanisms of antioxidants from nanoemulsion droplets are not yet fully understood. In this context, this review scrutinized the current formulation strategies to encapsulate antioxidant compounds and provide an outlook into the future of this research area by elucidating possible release mechanisms of antioxidant compounds from nanoemulsion system.
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Abbreviations
- CD:
-
Cyclodextrin
- O/W:
-
Oil-in-water
- PLA:
-
Polylactic acid
- PLGA:
-
Poly (lactic-co-glycolic acid)
- SEDDS:
-
Self-emulsifying drug delivery system
- SLN:
-
Solid lipid nanoparticles
- W/O:
-
Water-in-oil
- PDI:
-
Polydispersity index
- PIT:
-
Phase inversion temperature
- SEM:
-
Scanning electron microscopy
- TEM:
-
Transmission electron microscopy
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The authors wish to greatly appreciate Curtin University Malaysia for its financial support through the Curtin Malaysia Higher Degree Research (CMHDR) Grant.
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Ling, J.K.U., Chan, Y.S. & Nandong, J. Insights into the release mechanisms of antioxidants from nanoemulsion droplets. J Food Sci Technol 59, 1677–1691 (2022). https://doi.org/10.1007/s13197-021-05128-y
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DOI: https://doi.org/10.1007/s13197-021-05128-y