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Verification of the predictive validity for mortality of the SARC-F questionnaire based on a meta-analysis

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Abstract

Background

Although the association between SARC-F questionnaire positivity and mortality has previously been studied, the results are inconsistent. Testing the predictive validity of the SARC-F questionnaire for clinically relevant outcomes of vital prognoses is important.

Aim

The objective of this study was to test the predictive validity of SARC-F by conducting a meta-analysis on the association between SARC-F, a screening tool for sarcopenia, and mortality.

Methods

This meta-analysis used the MEDLINE, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, and Google Scholar databases for literature searches. Studies that examined the relationship between SARC-F questionnaire positivity and mortality and reported hazard ratios or odds ratios and 95% confidence intervals were included. A random-effects model was used for statistical analyses, and pooled hazard ratios, pooled odds ratios, and 95% confidence intervals were calculated.

Results

Through the literature search, we found five studies (7501 individuals) that met the eligibility criteria for this study. The pooled hazard ratio for SARC-F questionnaire positivity and mortality was 1.87 (95% confidence interval 1.41–2.46; P < 0.001), indicating a significant association. The pooled odds ratio for SARC-F questionnaire positivity and mortality was 1.97 (95% confidence intervals 1.10–3.53; P = 0.02), showing a significant association.

Conclusions

There was a significant association between SARC-F positivity and future mortality, indicating the predictive validity of the SARC-F questionnaire.

Trial registration

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Acknowledgements

The authors would like to thank all the staff members of the Department of Diabetes and Metabolism at the Ise Red Cross Hospital for their cooperation in this study.

Funding

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Authors and Affiliations

  1. Department of Diabetes and Metabolism, Ise Red Cross Hospital, 1-471-21-chome, Ise-shi, FunaeMie, 516-8512, Japan

    Satoshi Ida, Ryutaro Kaneko, Kanako Imataka, Kaoru Okubo, Yoshitaka Shirakura, Kentaro Azuma, Ryoko Fujiwara, Hiroka Takahashi & Kazuya Murata

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  1. Satoshi Ida
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  3. Kanako Imataka
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  7. Ryoko Fujiwara
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  9. Kazuya Murata
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Contributions

SI carried out the design of the study and drafted the manuscript; KM worked on giving advice and reviewing from a medical point of view; RK, KI, KO, YS, KA, RF, and HT helped in the drafting of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Satoshi Ida.

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Ida, S., Kaneko, R., Imataka, K. et al. Verification of the predictive validity for mortality of the SARC-F questionnaire based on a meta-analysis. Aging Clin Exp Res 33, 835–842 (2021). https://doi.org/10.1007/s40520-020-01585-1

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