Skip to main content

Modulation of the Immune Response Through 4-1BB

  • Chapter
  • First Online:
Cancer Gene Therapy

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 465))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alderson, MR., Smith, C.A., Tough, T.W., Davis-Smith, T., Armitage, R.J., Falk, B., Roux, E., Baker, E., Sutherland, G.R., and Din, W.S., 1994, Molecular and biological characterization of human 4-1BB and its ligand, Eur J Immunol 24(9):2219–2227.

    PubMed  CAS  Google Scholar 

  • Arch, R.H., and Thompson, C.B., 1998, 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB, Mol Cell Biol 18(1):558–565.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Chen, L., 1998, Immunological ignorance of silent antigens as an explanation of tumor evasion, Immunol Today 19(1):27–30.

    PubMed  CAS  Google Scholar 

  • Chen, L., Ashe, S., Brady, W.A., Hellstrom, I., Hellstrom, K.E., Ledbetter, J.A., McGowan, P., and Linsley, P.S., 1992, Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4, Cell 71(7):1093–1102.

    PubMed  CAS  Google Scholar 

  • Chouaib, S., Asselin-Paturel, C., Mami-Chouaib, F., Caignard, A., and Blay, J.Y., 1997, The host-tumor immune conflict: from immunosuppression to resistance and destruction, Immunol Today 18(10):493–497.

    PubMed  CAS  Google Scholar 

  • Chu, N.R., DeBenedette, M.A., Stiernholm, B.J., Barber, B.H., and Watts, T.H., 1997, Role of IL-12 and 4-1BB ligand in cytokine production by CD28+ and CD28-T cells, J Immunol 158(7):3081–3089.

    PubMed  CAS  Google Scholar 

  • DeBenedette, M.A., Chu, N.R., Pollok, K.E., Hurtado, J., Wade, W.F., Kwon, B.S., and Watts, T.H., 1995, Role of 4-1BB Ligand in costimulation of T lymphocyte growth and its upregulation on M12 B lymphomas by cAMP, J Exp Med 181(3):985–992.

    PubMed  CAS  Google Scholar 

  • DeBenedette, M.A., Shahinian, A., Mak, T.W., and Watts, T.H., 1997, Costimulation of CD28-T lymphocytes by 4-1BB Iigand, J Immunol 158(2):551–559.

    PubMed  CAS  Google Scholar 

  • Garni-Wagner, B.A., Lee, Z.H., Kim, Y.J., Wilde, C., Kang, C.Y., and Kwon, B.S., 1996, 4-1BB is expressed on CD45RAhiROhi transitional T cell in humans, Cell Immunol 169(1):91–98.

    PubMed  CAS  Google Scholar 

  • Goodwin, R.G., Din, W.S., Davis-Smith, T., Anderson, D.M., Gimpel, S.D., Sato, T.A., Maliszewski, C.R., Brannan, C.I., Copeland, N.G., Jenkins, N.A., and et al., 1993, Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor, Eur J Immunol 23(10):2631–2641.

    PubMed  CAS  Google Scholar 

  • Hellstrom, K.E., Hellstrom, I., and Chen, L., 1995, Can co-stimulated tumor immunity be therapeutically efficacious?, Immunol Rev 145:123–145.

    PubMed  CAS  Google Scholar 

  • Hurtado, J.C., Kim, S.H., Pollok, K.E., Lee, Z.H., and Kwon, B.S., 1995, Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28, J Immunol 155(7):3360–3367.

    PubMed  CAS  Google Scholar 

  • Jang, I.K., Lee, Z.H., Kim, Y.J., Kim, S.H., and Kwon, B.S., 1998, Human 4-IBB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B, Biochem Biophys Res Commun 242(3):613–620.

    PubMed  CAS  Google Scholar 

  • Kim, Y.J., Kim, S.H., Mantel, P., and Kwon, B.S., 1998, Human 4-1BB regulates CD28 co-stimulation to promote ThI cell responses, Eur J Immunol 28(3):881–890.

    PubMed  CAS  Google Scholar 

  • Kim, Y.J., Pollok, K.E., Zhou, Z., Shaw, A., Bohlen, J.B., Fraser, M., and Kwon, B.S., 1993, Novel Tcell antigen 4-1BB associates with the protein tyrosine kinase p561ckl, J Immunol 151(3):1255–1262.

    PubMed  CAS  Google Scholar 

  • Kwon, B.S., Kestler, D.P., Eshhar, Z., Oh, K.O., and Wakulchik, M., 1989, Expression characteristics of two potential T cell mediator genes, Cell Immunol 121(2):414–422.

    PubMed  CAS  Google Scholar 

  • Langstein, J., Michel, J., Fritsche, J., Kreutz, M., Andreesen, R., and Schwarz, H., 1998, CD137 (ILA/4-1BB), a member of the TNF receptor family, induces monocyte activation via bidirectional signaling, J Immunol 160(5):2488–2494.

    PubMed  CAS  Google Scholar 

  • Li, Y., Hellstrom, K.E., Newby, S.A., and Chen, L., 1996, Costimulation by CD48 and B7-1 induces immunity against poorly immunogenic tumors, J Exp Med 183(2):639–644.

    PubMed  CAS  Google Scholar 

  • Melero, I., Bach, N., Hellstrom, K.E., Aruffo, A., Mittler, R.S., and Chen, L., 1998a, Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway, Eur J Immunol 28(3): 1116–1121.

    PubMed  CAS  Google Scholar 

  • Melero, I., Johnston, J.V., Shufford, W.W., Mittler, R.S., and Chen, L., 1998b, Cell Immunol in press.

    Google Scholar 

  • Melero, I., Shuford, W.W., Newby, S.A., Aruffo, A., Ledbetter, J.A., Hellstrom, K.E., Mittler, R.S., and Chen, L., 1997, Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors, Nat Med 3(6):682–685.

    PubMed  CAS  Google Scholar 

  • Michel, J., Langstein, J., Hofstadter, F., and Schwarz, H., 1998, A soluble form of CD137 (ILA/4-1BB), a member of the TNF receptor family, is released by activated lymphocytes and is detectable in sera of patients with rheumatoid arthritis, Eur J Immunol 28(1):290–295.

    PubMed  CAS  Google Scholar 

  • Pinto, A., Aldinucci, D., Gloghini, A., Zagonel. V., Degan, M., Perin, V., Todesco, TM., De Iuliis, A., Improta, S., Sacco, C., Gattei, V., Gruss, H.J., and Carbone, A., 1997, The role of eosinophils in the pathobiology of Hodgkin’s disease, Ann Oncol 8 Suppl 2:89–96.

    PubMed  Google Scholar 

  • Pollok, K.E., Kim, S.H., and Kwon, B.S., 1995, Regulation of 4-1BB expression by cell-cell interactions and the cytokines, interleukin-2 and interleukin-4, Eur J Immunol 25(2):488–494.

    PubMed  CAS  Google Scholar 

  • Pollok, K.E., Kim, Y.J., Hurtado, J., Zhou, Z., Kim, K.K., and Kwon, B.S., 1994, 4-1BB T-cell antigen binds to mature B cells and macrophages, and costimulates anti-mu-primed splenic B cells, Eur J Immunol 24(2):367–374.

    PubMed  CAS  Google Scholar 

  • Pollok, K.E., Kim, Y.J., Zhou, Z., Hurtado, J., Kim, K.K., Pickard, R.T., and Kwon, B.S., 1993, Inducible T cell antigen 4-1BB. Analysis of expression and function, J Immunol 150(3):771–781.

    PubMed  CAS  Google Scholar 

  • Saoulli, K., Lee, S.Y., Cannons, J.L., Yeh, W.C., Santana, A., Goldstein, M.D., Bangia, N., DeBenedette, M.A., Mak, T.W., Choi, Y., and Watts, T.H., 1998, CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand, J Exp Med 187(11):1849–1862.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Schwarz, H., Blanco, F.J., von Kempis, J., Valbracht, J., and Lotz, M., 1996, ILA, a member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival, Blood 87(7):2839–2845.

    PubMed  CAS  Google Scholar 

  • Setareh, M., Schwarz, H., and Lotz, M., 1995, A mRNA variant encoding a soluble form of 4-1BB, a member of the murine NGF/TNF receptor family, Gene 164(2):311–315.

    PubMed  CAS  Google Scholar 

  • Shuford, W.W., Klussman, K., Tritchler, D.D., Loo, D.T., Chalupny, J., Siadak, A.W., Brown, T.J., Emswiler, J., Raecho, H., Larsen, C.P., Pearson, T.C., Ledbetter, J.A., Aruffo, A., and Mittler, R.S., 1997, 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses, J Exp Med 186(1):47–55.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Zhou, Z., Pollok, K.E., Kim, K.K., Kim, Y.J., and Kwon, B.S., 1994, Functional analysis of T-cell antigen 4-1BB in activated intestinal intra-epithelial T lymphocytes, Immunol Lett 41(2–3):177–184.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

Sica, G., Chen, L. (2002). Modulation of the Immune Response Through 4-1BB. In: Habib, N.A. (eds) Cancer Gene Therapy. Advances in Experimental Medicine and Biology, vol 465. Springer, New York, NY. https://doi.org/10.1007/0-306-46817-4_30

Download citation

  • DOI: https://doi.org/10.1007/0-306-46817-4_30

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-306-46191-0

  • Online ISBN: 978-0-306-46817-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics