Skip to main content
SpringerLink
Log in

Myelodysplastic/Myeloproliferative Diseases

  • Chapter
Hematopathology in Oncology

Part of the book series: Cancer Treatment and Research ((CTAR,volume 121))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bennett J.M., Catovsky D., Daniel M.T., et al. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 1982;51:189–199.

    CAS  PubMed  Google Scholar 

  2. Michaux J.L., Martiat P. Chronic myelomonocytic leukaemia (CMML) — a myelodysplastic or myeloproliferative syndrome? Leuk Lymph 1993;9:35–41.

    Article  CAS  Google Scholar 

  3. Bain B.J. The relationship between the myelodysplastic syndromes and the myeloproliferative disorders. Leuk Lymphoma 1999;34:443–449.

    CAS  PubMed  Google Scholar 

  4. Jaffe E.S., Harris N.L., Stein H., Vardiman J.W. (eds): World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press, 2001.

    Google Scholar 

  5. Neuwirtová R., Mociková K., Musilová J., et al. Mixed myelodysplastic and myeloproliferative syndromes. Leuk Res 1996;20:717–726.

    PubMed  Google Scholar 

  6. Emanuel P.D., Shannon K.M., Castleberry R.P. Juvenile myelomonocytic leukemia: molecular understanding and prospects for therapy. Mol Med Today 1996;2:468–475.

    CAS  PubMed  Google Scholar 

  7. Hasle H., Niemeyer C.M., Chessells J.M., et al. A pediatric approach to the WHO classification of myelodysplastic and myeloproliferative disease. Leukemia 2003;17:277–282.

    CAS  PubMed  Google Scholar 

  8. Cogswell P.C., Morgan R., Dunn M., et al. Mutations of the Ras protooncogenes in chronic myelogenous leukemia: a high frequency of Ras mutations in bcr/abl rearrangement-negative chronic myelogenous leukemia. Blood 1989;74:2629–2633.

    CAS  PubMed  Google Scholar 

  9. Hirsch-Ginsberg C., LeMaistre A.C., Kantarjian H., et al. RAS mutations are rare events in Philadelphia chromosome-negative/bcr gene rearrangement-negative chronic myelogenous leukemia, but are prevalent in chronic myelomonocytic leukemia. Blood 1990;76:1214–1219.

    CAS  PubMed  Google Scholar 

  10. Side L.E., Emanuel P.D., Taylor B., et al. Mutations of the NF1 gene in children with juvenile myelomonocytic leukemia without clinical evidence of neurofibromatosis, type 1. Blood 1998;92:267–272.

    CAS  PubMed  Google Scholar 

  11. Tartaglia M., Niemeyer C.M., Fragele A., et al. Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Nat Genet 2003;34:148–150.

    Article  CAS  PubMed  Google Scholar 

  12. Golub T.R., Barker G.F., Lovett M., et al. Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 1994;77:307–316.

    Article  CAS  PubMed  Google Scholar 

  13. Carroll M., Tomasson M.H., Barker G.F., et al. The TEL/platelet-derived growth factor beta receptor (PDGFbetaR) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGFbeta R kinase-dependent signaling pathways. Proc Natl Acad Sci USA 1996:93:145–150.

    Article  Google Scholar 

  14. Tomasson M.H., Williams I.R., Hasserjian R., et al. TEL/PDGFbetaR induces hematologic malignancies in mice that respond to a specific tyrosine kinase inhibitor. Blood 1999;93:1707–1714.

    CAS  PubMed  Google Scholar 

  15. Kelly L., Clark. J, Gilliland D.G. Comprehensive genetic analysis of leukemia: clinical and therapeutic implications. Cur Opinion Oncol 2002;14:10–18.

    CAS  Google Scholar 

  16. Emanuel P.D. Myelodysplasia and myeloproliferative disorders in children: an update. Review. Br J Haematol 1999;103:852–863.

    Google Scholar 

  17. Suda T., Miura Y., Mizoguchi H., et al. Characterization of hematopoietic precursor cells in juvenile-type chronic myelocytic leukemia. Leuk Res 1982;6:43–53.

    Article  CAS  PubMed  Google Scholar 

  18. Emanuel P.D., Bates L.J., Castleberry R.P., et al. Selective hypersensitivity to granulocyte-macrophage colony-stimulating factor by juvenile chronic myeloid leukemia hematopoietic progenitors. Blood 1991;77:925–929.

    CAS  PubMed  Google Scholar 

  19. Busque L., Gilliland D.G., Prachal J.T., et al. Clonality in juvenile chronic myelomonocytic leukemia. Blood 1995;85:21–30.

    CAS  PubMed  Google Scholar 

  20. Freeburn R.W., Gale R.E., Wagner H.M., Linch D.C. Analysis of the coding sequence for the GM-CSF receptor alpha and beta chains in patients with juvenile chronic myeloid leukemia (JCML). Exp Hematol 1997;25:306–311.

    CAS  PubMed  Google Scholar 

  21. Miyauchi J., Asada M., Sasaki M., et al. Mutations of the N-ras gene in juvenile chronic myelogenous leukemia. Blood 1994;83:2248–2254.

    CAS  PubMed  Google Scholar 

  22. Flotho C., Valcamonica S., Mach-Pascual S., et al. RAS mutations and clonality analysis in children with juvenile myelomonocytic leukemia (JMML). Leukemia 1999;13:32–37.

    CAS  PubMed  Google Scholar 

  23. Side L., Taylor B., Cayouette M., et al. Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders. N Eng J Med 1997;336:1713–1720.

    CAS  Google Scholar 

  24. Martiat P., Michaux J.L., Rodhain J. for the Groupe Français de Cytogénétique Hématologique. Philadelphia-negative (Ph−) chronic myeloid leukemia (CML): comparison with Ph+ CML and chronic myelomonocytic leukemia. Blood 1991;78:205–211.

    CAS  PubMed  Google Scholar 

  25. Emanuel P.D., Zhu S.W., Bates L.J., Zuckerman K.S. Hypersensitivity to hemopoietic growth factors in chronic myelomonocytic leukemia. Blood 1991;78(Suppl.1), 567a.

    Google Scholar 

  26. Cambier N., Baruchei A., Schlageter M.H., et al. Chronic myelomonocytic leukemia: from biology to therapy. Hematology and Cell Therapy 1997;39:41–48.

    CAS  PubMed  Google Scholar 

  27. Ramshaw H.S., Bardy P.G., Lee M.A., et al. Chronic myelomonocytic leukemia requires granulocyte-macrophage colony-stimulation factor for growth in vitro and in vivo. Exp Hematol 2002;30:1124–1131.

    Article  CAS  PubMed  Google Scholar 

  28. Onida F., Kantarjian H.M., Smith T.L., et al. Prognostic factors and scoring systems in chronic myelomonocytic leukemia: a retrospective analysis of 213 patients. Blood 2002;99:840–849.

    Article  CAS  PubMed  Google Scholar 

  29. Groupe Francais de Cytogenetique Hematologique. Chronic myelomonocytic leukemia: Single entity or heterogeneous disorder? A prospective multicenter study of 100 patients. Cancer Genet Cytogenet 1991;55:57–65.

    Google Scholar 

  30. Toyama K., Ohyashiki K., Yoshida Y., Clinical implications of chromosomal abnormalities in 401 patients with myelodysplastic syndromes: a multicentric study in Japan. Leukemia 1993;7:499–508.

    CAS  PubMed  Google Scholar 

  31. Ross T.S., Bernard O.A., Berger R., Gilliland D.G. Fusion of Huntingtin interacting protein 1 to platelet derived growth factor beta receptor (PDGFbetareceptor) in chronic myelomonocytic leukemia with t(5;7)(q33;q11.2). Blood 1998;91:4419–4426.

    CAS  PubMed  Google Scholar 

  32. Magnusson M.K., Meade K.E., Nakamura R., et al. Activity of STI571 in chronic myelomonocytic leukemia with a platelet-derived growth factor beta receptor fusion oncogene. Blood 2002;100:1088–1091.

    Article  CAS  PubMed  Google Scholar 

  33. Wilbanks A.M., Mahajan S., Frank D.A., et al. TEL/PDGFbetaR fusion protein activates STAT1 and STAT5: a common mechanism for transformation by tyrosine kinase fusion proteins. Exp Hematol 2000;28:584–593.

    Article  CAS  PubMed  Google Scholar 

  34. Hernandez J.M., del Canizo M.C., Cuneo A., et al. Clinical, hematological and cytogenetic characteristics of atypical chronic myeloid leukemia. Ann Oncol 2000;11:441–444.

    Article  CAS  PubMed  Google Scholar 

  35. Shukralla N., Finiewicz K., Roulston D., et al. Is atypical chronic myeloid leukemia a high white count myelodysplastic disorder? Mod Pathol 1997;10:134a.

    Google Scholar 

  36. Baxter E.J., Hochhaus A., Bolufer P., et al. The t(4;22)(q12;q11) in atypical chronic myeloid leukemia fuses BCR to PDGFRalpha. Human Mol Genet 2002;11:1391–1397.

    CAS  Google Scholar 

  37. Trempat P., Villalva C., Laurent G., et al. Chronic myeloproliferative disorders with rearrangement of the platelet-derived growth factor alpha receptor: a new clinical target for STI571/Glivec. Oncogene 2003;22:5702–5706.

    Article  CAS  PubMed  Google Scholar 

  38. Siena S., Sammarelli G., Grimoldi M.G., et al. New reciprocal translocation t(5;10)q33;q22) associated with atypical chronic myeloid leukemia. Haematologica 1999;84:369–372.

    CAS  PubMed  Google Scholar 

  39. Aurich J., Duchayne E., Huguet-Rigal F., et al. Clinical, morphological, cytogenetic and molecular aspects of a series of Ph-negative chronic myeloid leukemias. Hematol Cel Ther 1998;40:149–158.

    CAS  Google Scholar 

  40. Niemeyer C.M., Arico M., Biondi A., et al. Chronic myelomonocytic leukemia in childhood: A retrospective analysis of 110 cases. Blood 1997;89:3534–3543.

    CAS  PubMed  Google Scholar 

  41. Hasle H., Arico M., Biondi A., et al. Myelodysplastic syndrome, juvenile myelomonocytic leukemia, and acute myeloid leukemia associated with complete or partial monosomy 7. Leukemia 1999;13:376–385.

    CAS  PubMed  Google Scholar 

  42. Arico M., Biondi A., Pui C.H. Juvenile myelomonocytic leukemia. Blood 1997;90:479–488.

    CAS  PubMed  Google Scholar 

  43. Pinkel D. Differentiating juvenile myelomonocytic leukemia from infectious disease. Blood 1998;91:365–367.

    CAS  PubMed  Google Scholar 

  44. Niemeyer C.M., Fenu S., Hasle H., et al. Response (letter); Differentiating juvenile myelomonocytic leukemia from infectious disease. Blood 1998;91:365–367.

    Google Scholar 

  45. Luna-Fineman S., Shannon K.M., Atwater S.K., et al. Myelodysplastic and myeloproliferative disorders of childhood: A study of 167 patients. Blood 1999;93:459–466.

    CAS  PubMed  Google Scholar 

  46. Hess J.L., Zutter M.M., Castleberry R.P., Emanuel P.D., Juvenile chronic myelogenous leukemia. Am J Clin Pathol 1996; 105:238–248.

    CAS  PubMed  Google Scholar 

  47. Herrod H., Dow L., Sullivan J. Persistent Epstein-Barr virus infection mimicking juvenile chronic myelogenous leukemia: Immunologic and hematologic studies. Blood 1983;61:1098–1105.

    CAS  PubMed  Google Scholar 

  48. Bennett J.M., Catovsky D., Daniel M.T., et al. The chronic myeloid leukaemias: guidelines for distinguishing chronic granulocytic, atypical chronic myeloid, and chronic myelomonocytic leukaemia: proposals by the French-American-British Cooperative Leukaemia Group. Br J Haematol 1994;87:746–754.

    CAS  PubMed  Google Scholar 

  49. Germing U., Gattermann N., Minning H., et al. Problems in the classification of CMML—dysplastic versus proliferative type. Leuk Res 1998;22:871–878.

    Article  CAS  PubMed  Google Scholar 

  50. Voglová J., Chrobák L., Neuwirtová R., et al. Myelodysplastic and myeloproliferative type of chronic myelomonocytic leukemia-distinct subgroups or two stages of the same disease? Leuk Res 2001;25:493–499.

    PubMed  Google Scholar 

  51. Fenaux P., Beuscart R., Lai J.L., et al. Prognostic factors in adult chronic myelomonocytic leukemia: an analysis of 107 cases. J Clin Oncol 1988;6:1417–1424.

    CAS  PubMed  Google Scholar 

  52. Storniolo A.M., Moloney W.C., Rosenthal D.S., et al. Chronic myelomonocytic leukemia. Leukemia 1990;4:766–770.

    CAS  PubMed  Google Scholar 

  53. Saif M.W., Hopkins J.L., Gore S.D. Autoimmune phenomena in patients with myelodysplastic syndromes and chronic myelomonocytic leukemia. Leuk Lymph 2002;43:2083–2092.

    Article  Google Scholar 

  54. Kouides P.A., Bennett J.M. Morphology and classification of the myelodysplastic syndromes and their pathologic variants. Semin Hematol 1996;33:95–110.

    CAS  PubMed  Google Scholar 

  55. Maschek H., Georgii A., Kaloutsi V., et al. Myelofibrosis in primary myelodysplastic syndromes: a retrospective study of 352 patients. Eur J Haematol 1992;48:208–214.

    CAS  PubMed  Google Scholar 

  56. Baddoura F.K., Hanson C., Chan W.C. Plasmacytoid monocyte proliferation associated with myeloproliferative disorders. Cancer 1992;69:1457–1467.

    CAS  PubMed  Google Scholar 

  57. Harris N.L., Demirjian Z. Plasmacytoid T-zone cell proliferation in a patient with chronic myelomonocytic leukemia. Histologic and immunohistologic characterization. Am J Surg Pathol 1991;15:87–95.

    CAS  PubMed  Google Scholar 

  58. Fenaux P., Jouet J.P., Zandecki M., et al. Chronic and subacute myelomonocytic leukaemia in the adult: a report of 60 cases with special reference to prognostic factors. Br J Haematol 1987;65:101–106.

    CAS  PubMed  Google Scholar 

  59. Solal-Celigny P., Desaint B., Herrera A., et al. Chronic myelomonocytic leukemia according to the FAB classification: analysis of 35 cases. Blood 1984;63:634–638.

    CAS  PubMed  Google Scholar 

  60. Shepherd P.C.A., Ganesan T.S., Galton D.A.G. Haematological classification of the chronic myeloid leukaemias. Bailliere’s Clinical Haematology 1987;1:887–906.

    CAS  PubMed  Google Scholar 

  61. Oscier D.G. Atypical chronic myeloid leukaemia, a distinct clinical entity related to the myelodysplastic syndrome? Br J Haematol 1996;92:582–586.

    Article  CAS  PubMed  Google Scholar 

  62. Felman P., Bryon P.A., Gentilhomme O., et al. The syndrome of abnormal chromatin clumping in leucocytes: a myelodysplastic disorder with proliferative features? Br J Haematol 1988;70:49–54.

    CAS  PubMed  Google Scholar 

  63. Invernizzi R., Custodi P., De Fazio P., et al. The syndrome of abnormal chromatin clumping in leucocytes: clinical and biological study of a case. Haematologica 1990;75:532–536.

    CAS  PubMed  Google Scholar 

  64. Brizard A., Huret J.L., Lamotte J.I., et al. Three cases of myelodysplastic-myeloproliferative disorder with abnormal chromatin clumping in granulocytes. Correspondence. Br J Haematol 1989;72:294–295.

    CAS  PubMed  Google Scholar 

  65. Bain B., Vardiman J.W., Imbert M., Pierre R. Myelodysplastic/myeloproliferative disease, unclassifiable, in Jaffe ES, Harris NL, Stein H, Vardiman JW (Eds): World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press, 2001.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, University of Chicago, Chicago, Illinois

    James W. Vardiman

Authors
  1. James W. Vardiman
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Michigan Medical School, Ann Arbor, Michigan

    William G. Finn

  2. Northwestern University Feinberg School of Medicine, Chicago, Illinois

    LoAnn C. Peterson

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Kluwer Academic Publishers

About this chapter

Cite this chapter

Vardiman, J.W. (2004). Myelodysplastic/Myeloproliferative Diseases. In: Finn, W.G., Peterson, L.C. (eds) Hematopathology in Oncology. Cancer Treatment and Research, vol 121. Springer, Boston, MA. https://doi.org/10.1007/1-4020-7920-6_2

Download citation

  • DOI: https://doi.org/10.1007/1-4020-7920-6_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4020-7919-1

  • Online ISBN: 978-1-4020-7920-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation