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Photoaging of Skin

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Skin Aging

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References

  1. Berneburg M, Gattermann N, Stege H, Grewe M, Vogelsang K, Ruzicka T, Krutmann J (1997) Chronically ultraviolet-exposed human skin shows a higher mutation frequency of mitochondrial DNA as compared to unexposed skin and the hematopoietic system. Photochem Photobiol 66:271–275

    CAS  PubMed  Google Scholar 

  2. Berneburg M, Grether-Beck S, Kurten V, Ruzicka T, Briviba K, Sies H, Krutmann J (1999) Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion. J Biol Chem 274:15345–15349

    Article  CAS  PubMed  Google Scholar 

  3. Berneburg M, Plettenberg H, Krutmann J (2000) Photoaging of human skin. Photodermatol Photoimmunol Photomed 16:239–244

    CAS  PubMed  Google Scholar 

  4. Berneburg M, Plettenberg H, Medve-Konig K, Pfahlberg A, Gers-Barlag H, Gefeller O, Krutmann J (2004) Induction of the photoaging-associated mitochondrial common deletion in vivo in normal human skin. J Invest Dermatol 122:1277–1283

    Article  CAS  PubMed  Google Scholar 

  5. Berneburg M, Gremmel T, Kurten V, Schroeder P, Hertel I, von Mikecz A, Wild S, Chen M, Declercq L, Matsui M, Ruzicka T, Krutmann J (2005) Creatine supplementation normalizes mutagenesis of mitochondrial DNA as well as functional consequences. J Invest Dermatol 125:213–220

    CAS  PubMed  Google Scholar 

  6. Bielenberg DR, Bucana CD, Sanchez R, Donawho CK, Kripke ML, Fidler IJ (1998) Molecular regulation of UVB-induced angiogenesis. J Invest Dermatol 111:864–872

    Article  CAS  PubMed  Google Scholar 

  7. Birch-Machin MA, Tindall M, Turner R, Haldane F, Rees JL (1998) Mitochondrial DNA deletions in human skin reflect photo-rather than chronologic aging. J Invest Dermatol 110:149–152

    Article  CAS  PubMed  Google Scholar 

  8. Blackburn EH (2001) Switching and signaling at the telomere. Cell 106:661–673

    Article  CAS  PubMed  Google Scholar 

  9. Brash D, Rudolph J, Simon J, Lin A, McKenna G, Baden H, Halperin A, Pontenm J (1991) A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Natl Acad Sci U S A 88:10124–10128

    CAS  PubMed  Google Scholar 

  10. Braverman IM, Fonferko E (1982) Studies in cutaneous aging: I. The elastic fibre network. J Invest Dermatol 78:434–443

    CAS  PubMed  Google Scholar 

  11. Braverman IM, Fonferko E (1982) Studies in cutaneous aging: II. The microvasculature. J Invest Dermatol 78:444–448

    CAS  PubMed  Google Scholar 

  12. Campisi J (2001) Cellular senescence as a tumorsuppressor mechanism. Trends Cell Biol 11:S27–31

    CAS  PubMed  Google Scholar 

  13. DeLeo VA, Dawes L, Jackson R (1981) Density of Langerhans cells (LC) in normal versus chronic actinically damaged skin (CADS) of humans. J Invest Dermatol 76:330–334

    Google Scholar 

  14. DiMauro S, Schon EA (2003) Mitochondrial respiratory-chain diseases. N Engl J Med 348:2656–2668

    Article  CAS  PubMed  Google Scholar 

  15. Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O, et al (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 92:9363–9367

    CAS  PubMed  Google Scholar 

  16. Eller MS, Yaar M, Gilchrest BA (1994) DNA damage and melanogenesis. Nature 372:413–414

    Article  CAS  PubMed  Google Scholar 

  17. Eller MS, Liou J, Gilchrest BA (2003) Disruption of the telomere loop induces pigmentation in normal human melanocytes. J Invest Dermatol 121

    Google Scholar 

  18. Fisher GJ, Wang ZQ, Datta SC, Varani J, Kang S, Voorhees JJ (1997) Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med 337:1419–1428

    Article  CAS  PubMed  Google Scholar 

  19. Fisher GJ, Talwar HS, Lin J, et al (1998) retinoic acid inhibits induction of c-jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo. J Clin Invest 101:1432–1440

    CAS  PubMed  Google Scholar 

  20. Fisher G, Datta S, Wang Z, Li X, Quan T, Chung J, Kang S, Voorhees J (2000) c-Jun dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoid acid. J Clin Invest 106:661–668

    Google Scholar 

  21. Gilchrest BA (2004) Using DNA damage responses to prevent and treat skin cancers. J Dermatol 31:862–877

    CAS  PubMed  Google Scholar 

  22. Gilchrest BA, Murphy GF, Soter NA (1982) Effects of chronologic aging and ultraviolet irradiation on Langerhans cells in human skin. J Invest Dermatol 79:85–88

    CAS  PubMed  Google Scholar 

  23. Greider CW (1996) Telomere length regulation. Annu Rev Biochem 65:337–65

    Article  CAS  PubMed  Google Scholar 

  24. Harley CB, Futcher AB, Greider CW (1990) Telomeres shorten during ageing of human fibroblasts. Nature 345:458–60

    Article  CAS  PubMed  Google Scholar 

  25. Hart RW, Setlow RB (1974) Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species. Proc Natl Acad Sci U S A 71:2169–73

    CAS  PubMed  Google Scholar 

  26. Jacobs HT (2003) The mitochondrial theory of aging: dead or alive? Aging Cell 2:11–7

    CAS  PubMed  Google Scholar 

  27. Kenyon C (2005) The plasticity of aging: insights from long-lived mutants. Cell 120:449–60

    Article  CAS  PubMed  Google Scholar 

  28. Kligman AM (1979) Perspectives and problems in cutaneous gerontology. J Invest Dermatol 73:39–46

    Article  CAS  PubMed  Google Scholar 

  29. Koch H, Wittern KP, Bergemann J (2001) In human keratinocytes the Common Deletion reflects donor variabilities rather than chronologic aging and can be induced by ultraviolet A irradiation. J Invest Dermatol 117:892–7

    Article  CAS  PubMed  Google Scholar 

  30. Lavker RM, Kligman A (1988) Chronic heliodermatitis: a morphologic evaluation of chronic actinic dermal damage with emphasis on the role of mast cells. J Invest Dermatol 90:325–330

    Article  CAS  PubMed  Google Scholar 

  31. Lee-Bellantoni MS (2005) Antioxidant defense and redox responses to telomere homolog oligonucleotides in human dermal fibroblasts: A model for investigating redox signaling responses to DNA damage. Department of Pathology & Laboratory Medicine, Division of Graduate Medical Science. Boston: Boston University School of Medicine

    Google Scholar 

  32. Levine RL, Stadtman ER (2001) Oxidative modification of protein during ageing. Exp Gerontol 36:1495–1502

    Article  CAS  PubMed  Google Scholar 

  33. Levy MZ, Allsopp RC, Futcher AB, Greider CW, Harley CB (1992) Telomere end-replication problem and cell aging. J Mol Biol 225:951–60

    Article  CAS  PubMed  Google Scholar 

  34. Li GZ, Eller MS, Firoozabadi R, Gilchrest BA (2003) Evidence that exposure of the telomere 3′ overhang sequence induces senescence. Proc Natl Acad Sci U S A 100:527–31

    CAS  PubMed  Google Scholar 

  35. Lombard DB, Chua KF, Mostoslavsky R, Franco S, Gostissa M, Alt FW (2005) DNA repair, genome stability, and aging. Cell 120:497–512

    Article  CAS  PubMed  Google Scholar 

  36. Sander CS, Chang H, Salzmann S, Muller CS, Ekanayake-Mudiyanselage S, Elsner P, Thiele JJ (2002) Photoaging is associated with protein oxidation in human skin in vivo. J Invest Dermatol 118:618–625

    Article  CAS  PubMed  Google Scholar 

  37. Scharffetter-Kochanek K, Brenneisen P, Wenk J, et al (2000) Photoaging of the skin: From phenotype to mechanisms. Exp Gerontol 35:307–316

    CAS  PubMed  Google Scholar 

  38. Smith JG, Davidson EA, Sams WM, Clark RD (1962) Alterations in human dermal connective tissue with age and chronic sun damage. J Invest Dermatol 39:347–350

    CAS  PubMed  Google Scholar 

  39. Stewart SA, Ben-Porath I, Carey VJ, O’Connor BF, Hahn WC, Weinberg RA (2003) Erosion of the telomeric single-strand overhang at replicative senescence. Nat Genet 33:492–6

    Article  CAS  PubMed  Google Scholar 

  40. Talwar HS, Griffiths CE, Fisher GJ, Hamilton TA, Voorhees JJ (1995) Reduced type I and type III pro-collagens in photodamaged adult human skin. J Invest Dermatol 105:285–29041

    Article  CAS  PubMed  Google Scholar 

  41. Trifunovicz A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder E, Bohlooly YM, Gidlof S, Oldfors A, Wibom R, Tornell J, Jacvobs HT, Lrsson NG (2004) Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429:417–42342

    Google Scholar 

  42. van Steensel B, Smogorzewska A, de Lange T (1998) TRF2 protects human telomeres from end-to-end fusions. Cell 92:401–13

    PubMed  Google Scholar 

  43. Varani J, Schuger L, Dame MK, Leonhard Ch, Fligiel SEG, Kang S, Fisher GJ, Vorhees JJ (2004) Reduced fibroblast interaction with intact collagen as a mechanism for depressed collagen synthesis in photodamaged skin. J Invest Dermatol 122:1471–1479

    Article  CAS  PubMed  Google Scholar 

  44. Vijg J (2000) Somatic mutations and aging: a reevaluation. Mutat Res 447:117–135

    CAS  PubMed  Google Scholar 

  45. von Zglinicki T (2000) Role of oxidative stress in telomere length regulation and replicative senescence. Ann N Y Acad Sci 908:99–110

    Google Scholar 

  46. von Zglinicki T, Saretzki G, Ladhoff J, d’Adda di Fagagna F, Jackson SP (2000) Human cell senescence as a DNA damage response. Mech Ageing Dev 126:111–7

    Google Scholar 

  47. Wallace DC (1992) Mitochondrial genetics: a paradigm for aging and degenerative diseases? Science 256:628–632

    CAS  PubMed  Google Scholar 

  48. Wenk J, Brenneisen P, Meewes C, Wlaschek M, Peters T, Blaudschun R, Ma W, Kuhr L, Schneider L, Scharffetter-Kochanek K (2001) UV-induced oxidative stress and photoaging. Curr Probl Dermatol 29:83–94

    CAS  PubMed  Google Scholar 

  49. Yang JH, Lee HC, Wei YH (1995) Photoageing-associated mitochondrial DNA length mutations in human skin. Arch Dermatol Res 287:641–8

    CAS  PubMed  Google Scholar 

  50. Yano K, Ouira H, Detmar M (2002) Targeted over expression of the angiogenesis inhibitor thrombospondin-1 in the epidermis of transgenic mice prevents ultraviolet-B-induced angiogenesis and cutaneous photodamage. J Invest Dermatol 118:800–805

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Environmental Health Research Institute (IUF), Auf’m Hennekamp 50, 40225, Düsseldorf, Germany

    Jean Krutmann

  2. Department of Dermatology, Boston University School of Medicine, 609 Albany Street, Boston, MA, 02118, USA

    Barbara A. Gilchrest

Authors
  1. Jean Krutmann
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  2. Barbara A. Gilchrest
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Editor information

Editors and Affiliations

  1. Department of Dermatology, Boston University School of Medicine, 609 Albany Street, Boston, MA, 02118, USA

    Barbara A. Gilchrest

  2. Institut für Umweltmedizinische Forschung (IUF) at the Heinrich-Heine-University, Düsseldorf gGmbH, Auf’m Hennekamp 50, 40225, Düsseldorf, Germany

    Jean Krutmann

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© 2006 Springer-Verlag Berlin Heidelberg

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Krutmann, J., Gilchrest, B.A. (2006). Photoaging of Skin. In: Gilchrest, B.A., Krutmann, J. (eds) Skin Aging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-32953-6_4

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  • DOI: https://doi.org/10.1007/3-540-32953-6_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-24443-1

  • Online ISBN: 978-3-540-32953-4

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