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The Role of HLA in MS Susceptibility and Phenotype

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Emerging and Evolving Topics in Multiple Sclerosis Pathogenesis and Treatments

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 26))

Abstract

One of the most consistent findings in multiple sclerosis (MS) is that development of MS is linked with carriage of the class II human leucocyte antigen (HLA) molecule HLA-DRB1*15:01; around 60 % of Caucasian MS patients carry this allele compared to 25–30 % of ethnically matched healthy individuals. However, other HLA molecules have also been linked to the development of MS. In this chapter, the association between different HLA types and susceptibility to MS will be reviewed, and other linkages between the carriage of specific HLA molecules and clinical and experimental findings in MS will be considered.

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  1. The University of Queensland, UQ Centre for Clinical Research, Building 71/918 Riyal Brisbane and Women’s Hospital, Brisbane, QLD, 4029, Australia

    Judith M. Greer

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  1. School of Biological Sciences, Malaghan Institute of Medical Research, Victoria University of Wellington School of Biological Sciences, Wellington, Wellington, New Zealand

    Anne C. La Flamme

  2. Department of Biochemistry, School of Molecular Sciences La Trobe Institute for Molecular Science, Melbourne, Australia

    Jacqueline Monique Orian

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Greer, J.M. (2014). The Role of HLA in MS Susceptibility and Phenotype. In: La Flamme, A., Orian, J. (eds) Emerging and Evolving Topics in Multiple Sclerosis Pathogenesis and Treatments. Current Topics in Behavioral Neurosciences, vol 26. Springer, Cham. https://doi.org/10.1007/7854_2014_357

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