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Immunoregulatory Roles for Fc Receptor-Like Molecules

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Negative Co-Receptors and Ligands

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 350))

Abstract

Fc receptor-like (FCRL) molecules comprise a family of imunoregulatory transmembrane proteins that are preferentially, but not exclusively expressed on B lineage cells. A strong regulatory potential on B cell activation has been characterized for the different FCRL proteins, but their biological roles are just beginning to be elucidated. We review recent advances in the understanding of FCRL1-6 expression and function, and indicate their potential roles in the pathogenesis of immunodeficiencies, lymphoid malignancies and autoimmune diseases.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA

    Götz R. A. Ehrhardt & Max D. Cooper

  2. Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, 30322, USA

    Götz R. A. Ehrhardt & Max D. Cooper

  3. Georgia Research Alliance, Atlanta, GA, 30303, USA

    Max D. Cooper

  4. Emory Center for AIDS Research, Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA

    Max D. Cooper

Authors
  1. Götz R. A. Ehrhardt
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  2. Max D. Cooper
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Correspondence to Max D. Cooper .

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Editors and Affiliations

  1. Emory Vaccine Center &, Yerkes National Primate Research Center, Emory University, Gatewood Rd. 954, Atlanta, 30329, Georgia, USA

    Rafi Ahmed

  2. Fac. Medicine, Dept. Medical Chemistry and Molecular, Kyoto University, Yoshida Konoe-cho, Kyoto, 606-8501, Japan

    Tasuku Honjo

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Ehrhardt, G.R.A., Cooper, M.D. (2010). Immunoregulatory Roles for Fc Receptor-Like Molecules. In: Ahmed, R., Honjo, T. (eds) Negative Co-Receptors and Ligands. Current Topics in Microbiology and Immunology, vol 350. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2010_88

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