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Transplantation of Bone Marrow Stromal Cells for Treatment of Central Nervous System Diseases

  • Conference paper
Tissue Engineering

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 585))

Abstract

In this review article, we primarily focus on data generated in our laboratory using bone marrow stromal cells (BMSCs) for the treatment of stroke, and other central nervous system (CNS) disorders, such as traumatic brain injury, intracerebral hemorrhage, spinal cord injury, Parkinson’s disease, multiple sclerosis and brain tumor in rodents. BMSCs obtained from donor rats, mice or humans have been transplanted into the CNS via local and systemic routes. BMSCs selectively target damaged tissue, promote neurological functional recovery, and remodel brain architecture. Although some BMSCs express proteins phenotypic of neural cells, it is highly unlikely that benefit is derived by replacement of damaged tissues and rewiring brain with transdifferentiated BMSCs. The far more reasonable explanation is that BMSCs secrete and induce within parenchymal cells expression of growth or trophic factors that activate endogenous restorative processes, e.g., angiogenesis, synaptogenesis, gliogenesis and neurogenesis (Figure 4.1).

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Authors and Affiliations

  1. Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan, USA

    Michael Chopp & Yi Li

  2. Department of Physics, Oakland University, Rochester, Michigan, USA

    Michael Chopp

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  1. Michael Chopp
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  1. University of Maryland, College Park, MD, 20742, USA

    John P. Fisher

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Chopp, M., Li, Y. (2006). Transplantation of Bone Marrow Stromal Cells for Treatment of Central Nervous System Diseases. In: Fisher, J.P. (eds) Tissue Engineering. Advances in Experimental Medicine and Biology, vol 585. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-34133-0_4

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  • DOI: https://doi.org/10.1007/978-0-387-34133-0_4

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