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Brain Metastases in Hematologic Malignancies

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Brain Metastases

Part of the book series: Cancer Treatment and Research ((CTAR,volume 136))

Abstract

Central nervous system (CNS) involvement in patients with hematologic malignancies is a challenging clinical problem which carries a poor prognosis [1–5]. Hematopoietic and lymphoid neoplasms involve the CNS with varying frequencies. For example, long term disease control in childhood acute lymphoblastic leukemia (ALL) was rare before the recognition of occult CNS disease at diagnosis [6, 7]. Patient outcomes and cure rates dramatically improved once adequate prophylaxis against CNS disease was instituted in the 1970’s, as part of standard treatment for childhood ALL [6–8].

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Authors and Affiliations

  1. Department of Neurology, Oregon Health & Science University, Portland, OR, 97239-3098, USA

    Nancy D. Doolittle PhD

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  1. Nancy D. Doolittle PhD
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Editors and Affiliations

  1. Feinberg School of Medicine Robert H. Lurie Comprehensive Cancer Center Department of Neurology, Northwestern University, Chicago, IL, 60611, USA

    Jeffrey J. Raizer MD

  2. Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10021, USA

    Lauren E. Abrey MD

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Doolittle, N.D. (2007). Brain Metastases in Hematologic Malignancies. In: Raizer, J.J., Abrey, L.E. (eds) Brain Metastases. Cancer Treatment and Research, vol 136. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-69222-7_9

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  • DOI: https://doi.org/10.1007/978-0-387-69222-7_9

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