Abstract
Episodic hypoxia is associated with recurrent apnea syndromes (central or obstructive apneas). Epidemiological studies have shown good correlation between apneas and hypertension, myocardial infarctions and abnormalities in ventilatory control system (Nieto et al., 2000). Studies on experimental animal models have demonstrated that hypoxia, rather than hypercapnia, is the-primary stimulus that is responsible for developing cardiovascular abnormalities (see Fletcher, 2001 for ref).
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Peng, Y., Yuan, G., Overholt, J.L., Kumar, G.K., Prabhakar, N.R. (2003). Systemic and Cellular Responses to Intermittent Hypoxia: Evidence for Oxidative Stress and Mitochondrial Dysfunction. In: Pequignot, JM., Gonzalez, C., Nurse, C.A., Prabhakar, N.R., Dalmaz, Y. (eds) Chemoreception. Advances in Experimental Medicine and Biology, vol 536. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9280-2_71
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DOI: https://doi.org/10.1007/978-1-4419-9280-2_71
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