Abstract
Defining the cellular and molecular bases of embryo implantation is an important yet extremely difficult problem in developmental biology because of the lack of an appropriate in vitro model for implantation. In this regard two human cell lines, HT-H and SNG-M, are noteworthy, as these cells appear to mimic some, if not all, of the mechanisms involved in implantation. In particular, their unique manner of initial attachment at their respective apical cell surfaces and subsequent morphological changes leading to stronger adhesive interactions resemble the trophectoderm cells of blastocyst and endometrial epithelial cells at the implantation stage (1).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Fukuda MN, Sato T, Nakayama J, Klier G, Mikami M, Aoki D, et al. Trophinin and tastin: a novel cell adhesion complex with potential involvement in embryo implantation. Genes Devel 1995;9:1199–210.
Izhar M, Siebert P, Oshima RG, DeWolf WC, Fukuda MN. Trophoblastic differentiation of human teratocarcinoma cell line HT-H. Devel Biol 1986;116:510–8.
Ishiwata I, Nozawa S, Inoue T, Okumura H. Development and characterization of established cell lines from primary and metastatic regions of human endometrial carcinomas. Cancer Res 1977;37:1777–85.
Suzuki N, Fukuda MN. A novel cytoplasmic protein, bystin, interacts with trophinin and tastin, the molecules with potential involvement in implantation. In: Gomel V, Leung PCK, eds. In vitro fertilization and assisted reproduction. Bologna, Italy: (Monduzzi) 1997:759–64.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer Science+Business Media New York
About this chapter
Cite this chapter
Fukuda, M.N., Nadano, D., Suzuki, N., Nakayama, J. (1999). Potential Involvement of Trophinin, Bystin, and Tastin in Embryo Implantation. In: Carson, D.D. (eds) Embryo Implantation. Proceedings in the Serono Symposia USA Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1548-6_11
Download citation
DOI: https://doi.org/10.1007/978-1-4612-1548-6_11
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-7188-8
Online ISBN: 978-1-4612-1548-6
eBook Packages: Springer Book Archive