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Depression and Substance Use

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Drug Abuse and Addiction in Medical Illness

Abstract

Depression and substance use disorders (SUD) commonly co-occur in adult [10, 13, 97] and adolescent samples [98, 99]. Epidemiological studies that have begun in childhood and adolescence and followed cohorts over time have provided valuable information on changes in prevalence, trajectories of comorbid associations, and in highlighting key issues about their underlying causal mechanisms. This chapter draws together recent findings in this area, using examples from a wide range of sources to highlight key themes emerging from both adult and adolescent research. We begin with an overview of the concurrent prevalence of depression and SUD in adult and adolescent samples. We then explore longitudinal patterns of depression and SUD comorbidity from adolescence to adulthood to illustrate the varying mechanisms now thought to contribute to this comorbidity. Finally, we consider the implications of these findings for clinical practice.

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References

  1. American Psychiatric Association. Diagnostic and statistical manual of mental health disorders. 4th ed. Washington DC: Author; 1994.

    Google Scholar 

  2. Libby AM, Orton HD, Stover SK, Riggs PD. What came first, major depression or substance use disorder? Clinical characteristics and substance use comparing teens in a treatment cohort. Addict Behav. 2005;30:1649–62.

    Article  PubMed  Google Scholar 

  3. Becker DF, Grilo CM. Prediction of drug and alcohol abuse in hospitalized adolescents: comparisons by gender and substance type. Behav Res Ther. 2006;44:1431–40.

    Article  PubMed  Google Scholar 

  4. Karlsson L, Pelkonen M, Ruuttu T, Kiviruusu O, Heilä H, Holi M, Kettunen K, Tuisku V, Tuulio-Henriksson A, Törrönen J, Marttunen M. Current comorbidity among consecutive adolescent psychiatric outpatients with DSM-IV mood disorders. Eur Child Adolesc Psychiatry. 2006;15:220–31.

    Article  PubMed  Google Scholar 

  5. Clark DB, Pollock N, Bukstein OG, Mezzich AC, Bromberger JT, Donovan JE. Gender and comorbid psychopathology in adolescents with alcohol dependence. J Am Acad Child Adolesc Psychiatry. 1997;36:1195–203.

    Article  PubMed  CAS  Google Scholar 

  6. Chinet L, Plancherel B, Bolognini M, Bernard M, Laget J, Daniele G, Halfon O. Substance use and depression. Comparative course in adolescents. Eur Child Adolesc Psychiatry. 2006;15:149–55.

    Article  PubMed  Google Scholar 

  7. Merikangas K, Gelernter C. Comorbidity for alcoholism and depression. Psychiatr Clin North Am. 1990;13:613–32.

    PubMed  CAS  Google Scholar 

  8. Rohde P, Lewinsohn PM, Seeley JR. Comorbidity of unipolar depression: II. Comorbidity with other mental disorders in adolescents and adults. J Abnorm Psychol. 1991;100:214–22.

    Article  PubMed  CAS  Google Scholar 

  9. Kessler RC, Nelson CB, McGonagle KA, Edlund MJ, Frank RG, Leaf PJ. The epidemiology of co-occurring addictive and mental disorders. Am J Orthopsychiatry. 1996;66:17–31.

    Article  PubMed  CAS  Google Scholar 

  10. Reiger DA, Farmer ME, Rae DS, Locke BZ, Keith SJ, Judd LL, Goodwin FK. Comorbidity of mental disorders with alcohol and other drug abuse: results from the Epidemiologic Catchment area (ECA) study. JAMA. 2000;264:2511–8.

    Google Scholar 

  11. Grant BF, Stinson FS, Dawson DA, Chou P, Dufour MC, Compton W, Pickering RP, Kaplan K. Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders. Arch Gen Psychiatry. 2004;61:807–16.

    Article  PubMed  Google Scholar 

  12. Haynes JC, Farrell M, Singleton N, Meltzer H, Araya R, Lewis G, Wiles NJ. Alcohol consumption as a risk factor for anxiety and depression: results from the longitudinal follow-up of the National Psychiatric Morbidity Survey. Br J Psychiatry. 2005;187:544–51.

    Article  PubMed  Google Scholar 

  13. Kessler RC, Crum RM, Warner LA, Nelson CB, Schulenberg J, Anthony JC. The lifetime co-occurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the National Comorbidity Survey. Arch Gen Psychiatry. 1997;54:313–21.

    Article  PubMed  CAS  Google Scholar 

  14. Costello JE, Erkanli A, Federman E, Angold A. Development of Psychiatric comorbidity with substance abuse in adolescents: effects of timing and sex. J Clin Child Psychol. 1999;28:298–311.

    Article  PubMed  CAS  Google Scholar 

  15. Dierker LC, Avenevoli SA, Merikangas KR, Flaherty BP, Stolar M. Association between psychiatric disorders and the progression of tobacco use behaviors. J Am Acad Child Adolesc Psychiatry. 2001;40:1159–67.

    Article  PubMed  CAS  Google Scholar 

  16. Costello JE, Mustillo S, Erkanli A, Keeler G, Angold A. Prevalence and development of psychiatric disorders in childhood and adolescence. Arch Gen Psychiatry. 2003;60:837–44.

    Article  PubMed  Google Scholar 

  17. Fergusson DM, Goodwin RD, Horwood LJ. Major depression and cigarette smoking: results of a 21-year longitudinal study. Psychol Med. 2003;33:1357–67.

    Article  PubMed  CAS  Google Scholar 

  18. Sung M, Erkanli A, Angold A, Costello EJ. Effects of age at first substance use and psychiatric comorbidity on the development of substance use disorders. Drug Alcohol Depend. 2004;75:287–99.

    Article  PubMed  Google Scholar 

  19. Measelle JR, Stice E, Hogansen JM. Developmental trajectories of co-occurring depressive, eating, anti-social and substance abuse problems in female adolescents. J Abnorm Psychol. 2006;115:524–38.

    Article  PubMed  Google Scholar 

  20. Hayatbakhsh MR, Najman JM, Jamrozik K, Mumun AA, Alati R, Bor W. Cannabis and anxiety and depression in young adults: a large prospective study. J Am Acad Child Adolesc Psychiatry. 2007;46:408–17.

    Article  PubMed  Google Scholar 

  21. Pardini D, Raskin White H, Stouthamer-Loeber M. Early adolescent psychopathology as a predictor of alcohol use disorders by young adulthood. Drug Alcohol Depend. 2007;88S:S38–49.

    Article  Google Scholar 

  22. Boyle MH, Offord DR. Psychiatric disorder and substance use in adolescence. Can J Psychiatry. 1991;36:699–705.

    PubMed  CAS  Google Scholar 

  23. Angold A, Costello EJ, Erkanli A, Worthman CM. Pubertal changes in hormonal levels and depression in girls. Psychol Med. 1999;29:1043–53.

    Article  PubMed  CAS  Google Scholar 

  24. Eley TC, Stevenson J. Using genetic analyses to clarify the distinction between depressive and anxious symptoms in children and adolescents. J Abnorm Child Psychol. 1999;27:105–14.

    Article  PubMed  CAS  Google Scholar 

  25. Scourfield J, Rice F, Thapar A, Harold GT, Martin N, McGuffin P. Depressive symptoms in children and adolescents: changing aetiological influences with development. J Child Psychol Psychiatry. 2003;44:968–76.

    Article  PubMed  Google Scholar 

  26. Yorbik O, Birmaher B, Axelson D, Williamson DE, Ryan ND. Clinical characteristics of depressive symptoms in children and adolescents with major depressive disorder. J Clin Psychiatry. 2004;65:1654–9.

    Article  PubMed  Google Scholar 

  27. Keenan K, Loeber R, Green S. Conduct disorder in girls: a review of the literature. Clin Child Fam Psychol Rev. 1999;2:3–19.

    Article  PubMed  CAS  Google Scholar 

  28. Smith LA, Foxcroft DR. Drinking in the UK: an exploration of trends. York: Joseph Rowntree Foundation; 2009.

    Google Scholar 

  29. McGue M, Slutske W, Iacono WG. Personality and substance use disorders: II. Alcoholism versus drug use disorders. J Consult Clin Psychol. 1999;67:394–404.

    Article  PubMed  CAS  Google Scholar 

  30. Landheim AS, Bakken K, Vaglum P. Impact of comorbid psychiatric disorders on the outcome of substance abusers: a six year prospective follow-up in two Norwegian counties. BMC Psychiatry. 2006;6:44.

    Article  PubMed  Google Scholar 

  31. Swahn MH, Bossarte RM, Sullivent EE. Age of alcohol use initiation, suicidal behavior, and peer and dating violence victimization and perpetration among high-risk, seventh-grade adolescents. Pediatrics. 2008;121:297–305.

    Article  PubMed  Google Scholar 

  32. McGue M, Iacono WG. The association of early adolescent problem behavior with adult psychopathology. Am J Psychiatry. 2005;162:1118–24.

    Article  PubMed  Google Scholar 

  33. Mueser KT, Drake RE, Wallach MA. Dual diagnosis: a review of etiological theories. Addict Behav. 1998;23:717–34.

    Article  PubMed  CAS  Google Scholar 

  34. Krueger RF, Hicks BM, Patrick CJ, Carlson SR, Iacono WG, McGue M. Etiological connections among substance dependence, antisocial behavior and personality: modeling the externalizing spectrum. J Abnorm Psychol. 2002;111:411–24.

    Article  PubMed  Google Scholar 

  35. Conrod PJ, Stewart S. A critical look at dual-focused cognitive-behavioral treatments for comorbid substance use and psychiatric disorders: strengths, limitations, and future directions. J Cogn Psychother. 2005;19:261–84.

    Article  Google Scholar 

  36. Brook DW, Brook J, Zhang C, Cohen P, Whiteman M. Drug use and the risk of major depressive disorder, alcohol dependence, and substance use disorders. Arch Gen Psychiatry. 2002;59:1039–44.

    Article  PubMed  Google Scholar 

  37. Fergusson DM, Boden JM, Horwood LJ. Test of causal links between alcohol abuse or dependence and major depression. Arch Gen Psychiatry. 2009;66:260–6.

    Article  PubMed  Google Scholar 

  38. Kendler KS, Prescott CA, Myers J, Neale MC. The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women. Arch Gen Psychiatry. 2003;60:929–37.

    Article  PubMed  Google Scholar 

  39. Khantzian EJ. The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. Am J Psychiatry. 1985;142:1259–64.

    PubMed  CAS  Google Scholar 

  40. Greeley J, Oei T. Alcohol and tension reduction. In: Leonard KE, Blane HT, editors. Psychological theories of drinking and alcoholism. New York: Guilford; 1999. p. 14–53.

    Google Scholar 

  41. Sher K, Levenson R. Risk for alcoholism and individual differences in the stress-response-dampening effect of alcohol. J Abnorm Psychol. 1982;91:350–67.

    Article  PubMed  CAS  Google Scholar 

  42. King SM, Iacono WG, McGue M. Childhood internalizing and internalizing psychopathology in the prediction of early substance use. Addiction. 2004;99:1548–9.

    Article  PubMed  Google Scholar 

  43. Sihvola E, Rose RJ, Dick DM, Pulkkinen L, Marttunen M, Kaprio J. Early onset depressive disorders predict the use of addictive substances in adolescence: a prospective study of adolescent Finnish twins. Addiction. 2008;103:2045–53.

    Article  PubMed  Google Scholar 

  44. Marmorstein NR. Longitudinal associations between alcohol problems and depressive symptoms: early adolescence through early adulthood. Alcohol Clin Exp Res. 2009;33:49–59.

    Article  PubMed  Google Scholar 

  45. Loeber R, Stouthamer-Loeber M, Raskin-White. Developmental aspects of delinquency and internalizing problems and their association with persistent juvenile substance use between ages 7 and 18. J Clin Child Psychol. 1999;28:322–32.

    Article  PubMed  CAS  Google Scholar 

  46. Degenhault L, Hall W, Lynskey M. Exploring the association between cannabis use and depression. Addiction. 2003;98:1493–504.

    Article  Google Scholar 

  47. Wittchen HU, Frohlich C, Behrendt S, Gunther A, Rehm J, Zimmermann P, Lieb R, Perkonigg A. Cannabis use and cannabis use disorders and their relationship to mental disorders: a 10-year prospective longitudinal community study in adolescents. Drug Alcohol Depend. 2007;88S:S60–70.

    Article  Google Scholar 

  48. Schuckit MA. Comorbidity between substance use disorders and psychiatric conditions. Addiction. 2006;101:76–88.

    Article  PubMed  Google Scholar 

  49. Brown SA, Inaba RK, Gillin JC, Schuckit MA, Stewart MA, Irwin MR. Alcoholism and affective disorder: clinical course of depressive symptoms. Am J Psychiatry. 1995;152:45–52.

    PubMed  CAS  Google Scholar 

  50. Bovasso GB. Cannabis abuse as a risk factor for depressive symptoms. Am J Psychiatry. 2001;158:2033–7.

    Article  PubMed  CAS  Google Scholar 

  51. Agosti V, Levin F. The effects of alcohol and drug dependence on the course of depression. Am J Addict. 2006;15:71–5.

    Article  PubMed  Google Scholar 

  52. Paljärvi T, Koskenvuo M, Poikolainen K, Kauhanen J, Sillanmäki L, Mäkelä P. Binge drinking and depressive symptoms: a 5-year population-based cohort study. Addiction. 2009;104:1168–78.

    Article  PubMed  Google Scholar 

  53. Brook JS, Cohen P, Brook DW. Longitudinal study of co-­occurring psychiatric disorders and substance use. J Am Acad Child Adolesc Psychiatry. 1998;37:322–30.

    Article  PubMed  CAS  Google Scholar 

  54. Patton GC, Coffey C, Carlin JB, Degenhardt L, Lynskey M, Hall W. Cannabis use and mental health in young people: cohort study. Br Med J. 2002;325:1195–8.

    Article  Google Scholar 

  55. Hussong AM, Hicks RE, Levy SA, Curran PJ. Specifying the relations between affect and heavy alcohol use among young adults. J Abnorm Psychol. 2001;110:449–61.

    Article  PubMed  CAS  Google Scholar 

  56. Jackson KM, Sher KJ. Alcohol use disorder and psychological distress: a prospective state-trait analysis. J Abnorm Psychol. 2003;112:599–613.

    Article  PubMed  Google Scholar 

  57. Fleming CB, Masan WA, Mazza JJ, Abott RD, Catalano RF. Latent growth internal of the relationship between depressive symptoms and substance use during adolescence. Psychol Addict Behav. 2008;22:186–97.

    Article  PubMed  Google Scholar 

  58. Mackie CJ, Castellanos-Ryan N, Conrod PJ. Personality moderates the longitudinal relationship between psychological symptoms and alcohol use in adolescents. Alcohol Clin Exp Res. 2011;35(4):703–16.

    Article  PubMed  Google Scholar 

  59. Wills TA, Sandy JM, Shinar O, Yaeger A. Contributions of positive and negative affect to adolescent substance use: test of a bidimensional model in a longitudinal study. Psychol Addict Behav. 1999;13:327–38.

    Article  Google Scholar 

  60. Krueger RF, Caspi A, Moffitt TE. Epidemiological personology: the unifying role of personality in population-based research on problem behaviors. J Pers. 2000;68:967–98.

    Article  PubMed  CAS  Google Scholar 

  61. Elkins IJ, McGue M, Malone S, Iacono WG. The effect of parental alcohol and drug disorders on adolescent personality. Am J Psychiatry. 2004;161:670–76.

    Article  PubMed  Google Scholar 

  62. Caspi A, Moffitt TE, Newman DL, Silva PA. Behavioural observations at the age of 3 years predict adults psychiatric disorders: longitudinal evidence from a birth cohort. Arch Gen Psychiatry. 1996;53:1033–9.

    Article  PubMed  CAS  Google Scholar 

  63. Cox BJ, McWilliams LA, Enns MW, Clara IP. Broad and specific personality dimensions associated with major depression in a nationally representative sample. Compr Psychiatry. 2004;45:246–53.

    Article  PubMed  Google Scholar 

  64. Eysenck BG, Eysenck HJ. Personality differences between prisoners and controls. Psychol Rep. 1977;40:1023–8.

    Article  Google Scholar 

  65. Costa PT, McCrae RR. Normal personality assessment in clinical practice: the NEO Personality Inventory. Psychol Assess. 1992;4:5–13.

    Article  Google Scholar 

  66. Clark LA, Watson D. Tripartate model of anxiety and depression: psychometric evidence and taxonomic implications. J Abnorm Psychol. 1991;100:316–36.

    Article  PubMed  CAS  Google Scholar 

  67. Fergusson DM, Woodward LJ. Mental health, educational and social role outcomes of depressed adolescents. Arch Gen Psychiatry. 2002;59:225–31.

    Article  PubMed  Google Scholar 

  68. Conrod PJ, Pihl RO, Stewart SH, Dongier M. Validation of a system of classifying female substance abusers on the basis of personality and motivational risk factors for substance abuse. Psychol Addict Behav. 2000;14:243–56.

    Article  PubMed  CAS  Google Scholar 

  69. Woicik PA, Stewart SH, Pihl RO, Conrod PJ. The Substance Use Risk Profile Scale: a scale measuring traits linked to reinforcement-specific substance use profiles. Addict Behav. 2009;34:1042–55.

    Article  PubMed  Google Scholar 

  70. Jaffee WB, D’Zurilla TJ. Personality, problem solving, and adolescent substance use. Behav Ther. 2009;40:93–101.

    Article  PubMed  Google Scholar 

  71. Clark DB. Serum tryptophan ratio and suicidal behavior in adolescents: a prospective study. Psychol Res. 2003;119:199–204.

    CAS  Google Scholar 

  72. Winokur G, Coryell W. Familial alcoholism in primary unipolar major depressive disorder. Am J Psychiatry. 1991;148:184–8.

    PubMed  CAS  Google Scholar 

  73. Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ. A longitudinal twin study of personality and major depression in women. Arch Gen Psychiatry. 1993;50:853–62.

    Article  PubMed  CAS  Google Scholar 

  74. Prescott CA, Aggen SH, Kendler KS. Sex-specific genetic influences on the comorbidity of alcoholism and major depression in a population-based sample of US twins. Arch Gen Psychiatry. 2000;57:803–11.

    Article  PubMed  CAS  Google Scholar 

  75. Kendler KS, Prescott CA. Genes, environment, and psychopathology: understanding the causes of psychiatric and substance use disorders. New York: Guilford; 2006.

    Google Scholar 

  76. Lyons MJ, Schultz M, Neale M, Brady K, Eisen S, Toomey R, Rhein A, Faraone S, Tsuang M. Specificity of familial vulnerability for alcoholism versus major depression in men. J Nerv Ment Dis. 2006;194:809–17.

    Article  PubMed  Google Scholar 

  77. Dick DM, Foroud T. Candidate genes for alcohol dependence: a review of genetic evidence from human studies. Alcohol Clin Exp Res. 2003;27:868–79.

    Article  PubMed  Google Scholar 

  78. Enoch M. Genetic and environmental influences on the development of alcoholism. Resilience vs. risk. Ann NY Acad Sci. 2006;1094:193–201.

    Article  PubMed  Google Scholar 

  79. Greenberg BD, Li Q, Lucas FR, Hu S, Sirota LA, Benjamin J, Lesch K-P, Hamer D, Murphy DL. Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample. Am J Med Genet. 2000;96:202–16.

    Article  PubMed  CAS  Google Scholar 

  80. Armeli S, Connor TS, Covault J, Tennen H, Kranzler HR. A serotonin transporter gene polymorphism (5-HTTLPR), drinking to cope motivation, and negative life events among college students. J Stud Alcohol Drugs. 2008;69:814–26.

    PubMed  Google Scholar 

  81. Clark DB, de Bellis MD, Lynch KG, Cornelius JR, Martin CS. Physical and sexual abuse, depression and alcohol use disorders in adolescents: onsets and outcomes. Drug Alcohol Depend. 2005;69:51–60.

    Article  Google Scholar 

  82. Sartor CE, Lynskey MT, Heath AC, Jacob T, True W. The role of childhood risk factors in initiation of alcohol use and progression to alcohol dependence. Addiction. 2007;102:216–25.

    Article  PubMed  Google Scholar 

  83. Wakschlag L, Pickett K, Cook E, Benowitz N, Leventhal B. Maternal smoking during pregnancy and severe antisocial behavior in offspring: a review. Am J Public Health. 2002;92:966–74.

    Article  PubMed  Google Scholar 

  84. O’Connor TG, Ben-Shlomo Y, Heron J, Golding J, Adams D, Glover V. Prenatal anxiety predicts individual differences in cortisol in pre-adolescent children. Biol Psychiatry. 2005;58:211–7.

    Article  PubMed  Google Scholar 

  85. Patton GC, McMorris BJ, Toumbourou JW, Hemphill SA, Donath S, Catalano RF. Puberty and the onset of substance use and abuse. Pediatrics. 2004;114:e300–6.

    Article  PubMed  Google Scholar 

  86. Walden B, McGue M, Iacono WG, Burt SA, Elkins I. Identifying shared environmental contributions to early substance use: the respective roles of peers and parents. J Abnorm Psychol. 2004;113:440–50.

    Article  PubMed  Google Scholar 

  87. Curran PJ, Stice E, Chassin L. The relation between adolescent alcohol use and peer alcohol use: a longitudinal random coefficients model. J Consult Clin Psychol. 1997;65:130–40.

    Article  PubMed  CAS  Google Scholar 

  88. Feske U, Tarter RE, Kirisci L, Gao Z, Reynolds M, Vanyukov M. Peer environment mediates parental history and individual risk in the etiology of cannabis use disorders in boys: a 10-year prospective study. Am J Drug Alcohol Abuse. 2008;34:307–20.

    Article  PubMed  Google Scholar 

  89. Miller-Johnson S, Lochman JE, Coie JD, Terry R, Hyman C. Comorbidity of conduct and depressive problems at sixth grade: substance use outcomes across adolescence. J Abnorm Child Psychol. 1998;26:221–32.

    Article  PubMed  CAS  Google Scholar 

  90. Marmorstein NR, Icono WG. Major depression and conduct disorder in a twin sample: gender, functioning, and risk for future psychopathology. J Am Acad Child Adolesc Psychiatry. 2003;42:225–33.

    Article  PubMed  Google Scholar 

  91. Carroll KM. Behavioural therapies for co-occurring substance use and mood disorders. Biol Disord. 2004;56:778–84.

    Google Scholar 

  92. Brown RA, Evans DM, Miller IW, Burgess ES, Mueller TI. Cognitive-behavioural treatment for depression in alcoholism. J Consult Clin Psychol. 1997;65:715–26.

    Article  PubMed  CAS  Google Scholar 

  93. Carroll KM, Nich C, Rounsaville BJ. Differential symptom reduction in depressed cocaine abusers treated with psychotherapy and pharmacotherapy. J Nerv Ment Dis. 1995;183:251–9.

    Article  PubMed  CAS  Google Scholar 

  94. Maude-Griffin PM, Hohenstein JM, Humfleet GL, Reilly PM, Tusel DJ, Hall SM. Superior efficacy of cognitive-behavioural therapy for urban crack cocaine abusers: main and matching effects. J Consult Clin Psychol. 1998;66:832–7.

    Article  PubMed  CAS  Google Scholar 

  95. Melartin TK, Rytsälä HJ, Leskelä US, Lestelä-Mielonen PS, Sokero TS, Isometsä ET. Current comorbidity of psychiatric disorders among DSM-IV major depressive disorder patients in psychiatric care in the Vantaa Depression Study. J Clin Psychiatry. 2002;63:126–34.

    Article  PubMed  Google Scholar 

  96. Grant BF, Harford TC. Comorbidity between DSM-IV alcohol use disorders and major depression: results of a national survey. Drug Alcohol Depend. 1995;39:197–206.

    Article  PubMed  CAS  Google Scholar 

  97. Swendsen JD, Merikangas KR. The comorbidity of depression and substance use disorder. Clin Psychol Rev. 2000;20:173–89.

    Article  PubMed  CAS  Google Scholar 

  98. Armstrong TD, Costello EJ. Community studies on adolescent substance use, abuse, or dependence and psychiatric comorbidity. J Consult Clin Psychol. 2002;70:1224–39.

    Article  PubMed  Google Scholar 

  99. Cerdá M, Sagdeo A, Galea S. Comorbid forms of psychopathology: key patterns and future research directions. Epidemiol Rev. 2008;30:155–77.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. National Addiction Centre, Institute of Psychiatry, King’s College London, 4 Windsor Walk, Denmark Hill, London, SE5 8AF, UK

    Clare J. Mackie & Patricia Conrod

  2. Department of Psychiatry and Behavioral Sciences, Clinical Neurosciences Division, Medical University of South Carolina, 67 President St, 250861, Charleston, SC, 29425, USA

    Kathleen Brady M.D., Ph.D.

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  1. Clare J. Mackie
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  2. Patricia Conrod
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  3. Kathleen Brady M.D., Ph.D.
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Correspondence to Clare J. Mackie .

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Editors and Affiliations

  1. Inst. Pharmaceutical Sciences, Department of Psychopharmacology, Utrecht University, Universiteitsweg 99, Utrecht, 3584CG, Netherlands

    Joris C. Verster

  2. Dept. Psychiatry, Medical University of South Carolina, President St. 67, Charleston, 29425, South Carolina, USA

    Kathleen Brady

  3. School of Medicine, Div. Alcoholism & Drug Abuse, New York University, First Ave. 550, New York, 10016, New York, USA

    Marc Galanter

  4. Institute of Psychiatry, King's College London, National Addiction Centre, Windsor Walk 4, London, SE5 8AF, United Kingdom

    Patricia Conrod

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Mackie, C.J., Conrod, P., Brady, K. (2012). Depression and Substance Use. In: Verster, J., Brady, K., Galanter, M., Conrod, P. (eds) Drug Abuse and Addiction in Medical Illness. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3375-0_21

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