Abstract
Autism spectrum disorder (ASD), also known as a pervasive developmental disorder (PDD), is a behaviorally defined neurodevelopmental disorder that is usually diagnosed in early childhood. Male children are disproportionately diagnosed with an ASD. Mercury (Hg), a heavy metal, is widespread and persistent in the environment. Mercury is a ubiquitous source of danger in fish, drugs, fungicides/herbicides, dental fillings, thermometers, and many other products. Elevated Hg concentrations may remain in the brain from several years to decades following exposure. This is important because investigators have long recognized that, among its detrimental health effects, Hg is a neurodevelopmental toxicant. It is known to cause problems in neuronal cell migration and division and can ultimately cause cell degeneration and death. Case reports of patients have described developmental regressions with symptoms of an ASD following fetal and/or early childhood Hg exposure. Epidemiological studies have linked exposure to Hg with an elevated risk of a patient being diagnosed with an ASD. Immune, sensory, neurological, motor, and behavioral dysfunctions similar to traits defining or associated with an ASD were reported following Hg intoxication with similarities to an ASD diagnosis that extend to the subject’s neuroanatomy, neurotransmitters, and biochemistry.
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Geier, M., Kern, J.K., King, P.G., Sykes, L., Geier, D.A. (2014). Mercury Induced Autism. In: Patel, V., Preedy, V., Martin, C. (eds) Comprehensive Guide to Autism. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4788-7_79
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DOI: https://doi.org/10.1007/978-1-4614-4788-7_79
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