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Prominent Role of Prominin in the Retina

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Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 777))

Abstract

Prominin molecules represent a new family of pentaspan membrane glycoproteins expressed throughout the animal kingdom. The name originates from its localization on membrane protrusion, such as microvilli, filopodia, lamellipodia, and microspikes. Following the original description in mouse and human, representative prominin members were found in fish (e.g., Danio rerio), amphibian (Ambystoma mexicanum, Xenopus laevis), worm (Caenorhabditis elegans), and flies (Drosophila melanogaster). Mammalian prominin-1 was identified as a marker of somatic and cancer stem cells and plays an essential role in the visual system, which contributed to increased interest of the medical field in this molecule. Here we summarize recent data from various fields, including Drosophila, which will aid to our understanding of its still elusive function.

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Acknowledgements

We thank Shirin Meher Pocha for critical comments on the manuscript. D.C. and E.K. are supported by the Deutsche Forschungsgemeinschaft SFB655.

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Authors and Affiliations

  1. Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307, Dresden, Germany

    Nagananda Gurudev & Elisabeth Knust Ph.D.

  2. Tissue Engineering Laboratories (BIOTEC), Technische Universität Dresden, Tatzberg 47-49, 01307, Dresden, Germany

    Mareike Florek & Denis Corbeil

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  1. Nagananda Gurudev
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  2. Mareike Florek
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  3. Denis Corbeil
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  4. Elisabeth Knust Ph.D.
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Correspondence to Elisabeth Knust Ph.D. .

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  1. , Biotechnological Centre (BIOTEC), Dresden University of Technology, Fetscherstr. 74, Dresden, 01307, Sachsen, Germany

    Denis Corbeil

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Gurudev, N., Florek, M., Corbeil, D., Knust, E. (2013). Prominent Role of Prominin in the Retina. In: Corbeil, D. (eds) Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology. Advances in Experimental Medicine and Biology, vol 777. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5894-4_4

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