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Upregulation of cytochrome p450 1a2 in chronic renal failure: does oxidized tryptophan play a role?

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Developments in Tryptophan and Serotonin Metabolism

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 527))

Abstract

Earlier studies from this laboratory have shown that L-tryptophan, after oxidation by either UV-irradiation or ozone induces aryl hydrocarbon receptor (AhR) transformation and binding of the liganded AhR complex to its specific DNA recognition site, thereby inducing transcription ofCyplalgene with concomitant increase of CYP1A1 protein and activity in cells in culture. In the present investigation, we investigated the expression of CYP1A2 in the liver and kidney in chronic renal failure (CRF). The results demonstrate that CYP1A2 protein abundance was upregulated in both the liver and kidney tissues of the CRF group compared to the sham-operated controls.

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Author information

Authors and Affiliations

  1. Division of Nephrology/Hypertension, Department of Medicine,University of California at Irvine, Irvine, CA, 92697-4066

    Ram K. Sindhu & Nosratola D. Vaziri

Authors
  1. Ram K. Sindhu
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  2. Nosratola D. Vaziri
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Editor information

Editors and Affiliations

  1. University of Padova, Padova, Italy

    Graziella Allegri , Carlo V. L. Costa  & Eugenio Ragazzi ,  & 

  2. University of Hamburg, Hamburg, Germany

    Hans Steinhart

  3. Istituto G. Gaslini, Genova Quarto, Italy

    Luigi Varesio

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Sindhu, R.K., Vaziri, N.D. (2003). Upregulation of cytochrome p450 1a2 in chronic renal failure: does oxidized tryptophan play a role?. In: Allegri, G., Costa, C.V.L., Ragazzi, E., Steinhart, H., Varesio, L. (eds) Developments in Tryptophan and Serotonin Metabolism. Advances in Experimental Medicine and Biology, vol 527. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0135-0_47

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  • DOI: https://doi.org/10.1007/978-1-4615-0135-0_47

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4939-6

  • Online ISBN: 978-1-4615-0135-0

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