Abstract
This chapter reviews the concepts underlying the initial evaluation and management of the intersex child by the endocrinologist. By definition, such a child has lack of concordance of various aspects of gender. These include chromosomal sex (46XX, 46XY or other), gonadal/reproductive sex (ovaries, Fallopean tubes and uterus vs. testes, seminal vesicles, prostate gland and ejaculatory ducts), genital sex (vagina and clitoris vs. penis and scrotum), and gender-specific behavior. Depending on chromosomal sex, most patients may be classified as incompletely masculinized males (46 XY, male pseudohermaphrodites or males with micropenis), excessively virilized females (46XX, female pseudohermaphrodites), and patients with abnormalities of sex chromosomes such as those with mixed gonadal dysgenesis. A large number of conditions may be associated with intersex states (Table1).
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White, P.C. (2002). The Endocrinologist’s Approach to the Intersex Patient. In: Zderic, S.A., Canning, D.A., Carr, M.C., Snyder, H.M. (eds) Pediatric Gender Assignment. Advances in Experimental Medicine and Biology, vol 511. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0621-8_7
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DOI: https://doi.org/10.1007/978-1-4615-0621-8_7
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