Abstract
A decrease in lacrimal and salivary gland secretion is a primary cause of dry eye and dry mouth. Sjögren’s syndrome is the leading cause of the aqueous tear-deficient type of dry eye. 1-3 It is an autoimmune disease occurring almost exclusively in females (> 90%) and involves an extensive lymphocytic infiltration of the lacrimal and salivary glands as well as destruction of epithelial cells. 1-3 No cure exists for this disease. Moreover, its exact etiology is largely unknown, but may involve numerous factors including those of viral, endocrine, neural, genetic and environmental origin. 2-4-5
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Zoukhri, D., Kublin, C.L. (2002). Impaired Neurotransmission in Lacrimal and Salivary Glands of a Murine Model of Sjögren’s Syndrome. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_144
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DOI: https://doi.org/10.1007/978-1-4615-0717-8_144
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