Abstract
Chemokines represent an ever-growing family of secreted proteins that function as potent mediators of inflammation (for review, see Luster, 1998). These molecules have been classified depending on the number and spacing of the first two conserved amino terminal cysteine residues into the C, CC, CXC, and CX3C family. Studies have shown that chemokines target specific leukocyte populations during periods of inflammation (Luster, 1998; Lane et al., 2000; Biddison et al., 1998; Kolb et al, 1999). In addition, chemokines have been shown to be prominently expressed following viral infection of the CNS (Lane et al, 1998; Cheret et al., 1997, Asensio and Campbell, 1997; Hoffman et al., 1999). However, the functional significance of chemokine expression within this environment has not been fully defined.
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Liu, M.T. et al. (2001). The CXC Chemokines IP-10 and Mig are Essential in Host Defense Following Infection with a Neurotropic Coronavirus. In: Lavi, E., Weiss, S.R., Hingley, S.T. (eds) The Nidoviruses. Advances in Experimental Medicine and Biology, vol 494. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1325-4_48
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DOI: https://doi.org/10.1007/978-1-4615-1325-4_48
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