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The Insulin-Like Growth Factor-II/Mannose-6-Phosphate Receptor: Structure, Function and Differential Expression

  • Chapter
Current Directions in Insulin-Like Growth Factor Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 343))

Abstract

The insulin like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor is a bifunc-tional binding protein that binds lysosomal enzymes bearing the M6P recognition marker and IGF-II at distinct binding sites (45, 52). In addition, transforming growth factor (TGF) beta precursor, thyroglobulin and proliferin, a protein which is expressed in rapidly proliferating cells are also recognized by this receptor (Table 1). In avian and amphibian cells the receptor lacks the binding site for IGF-II but serves as a binding protein for M6P bearing ligands (7,9,76). Almost all mammalian cells described until today express IGF-II/M6P receptors that bind both classes of ligands, namely M6P-containing glycoproteins and IGF-II (55–59).

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Authors and Affiliations

  1. Cell Biology Laboratory, Dept. Pediatric Endocrinology, Children’s Hospital, University of Munich, Lindwurmstr. 4, D-8000, Munich 2, Germany

    Wieland Kiess, Andreas Hoeflich & Ulrike Kessler

  2. Children’s Hospital, Medical University, Feng Li Rd., Shanghai, People’s Republic of China

    Yi Yang

  3. Institute of Experimental Clinical Research, Kommunehospitalet University of Aarhus, DK-8000, Aarhus, Denmark

    Allan Flyvbjerg

  4. Laboratoire de Croissance et Differenciation Cellulaire, INRA, Place Pierre Viala, F-Montpellier Cedex, France

    Bruno Barenton

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  1. Wieland Kiess
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Editors and Affiliations

  1. National Institutes of Health, Bethesda, Maryland, USA

    Derek Le Roith M.D., Ph.D.

  2. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada Ph.D.

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Kiess, W., Hoeflich, A., Yang, Y., Kessler, U., Flyvbjerg, A., Barenton, B. (1994). The Insulin-Like Growth Factor-II/Mannose-6-Phosphate Receptor: Structure, Function and Differential Expression. In: Le Roith, D., Raizada, M.K. (eds) Current Directions in Insulin-Like Growth Factor Research. Advances in Experimental Medicine and Biology, vol 343. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2988-0_18

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