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Effect of Taurine on Intracellular Calcium Dynamics of Cultured Myocardial Cells During the Calcium Paradox

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Taurine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 315))

Abstract

The “calcium paradox” phenomenon, first described by Zimmerman and Hulsman1, occurs when hearts are reperfused with calcium after a short period of calcium-free perfusion. The Ca2+ repletion phase causes irreversible myocardial damage, characterized by reduced electrical activity, extensive ultrastructural damage, depletion of tissue high-energy phosphate content, massive release of intracellular constituents and an increase in cytosolic Na+ and Ca2+2.

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Author information

Authors and Affiliations

  1. Department of Medicine III, Osaka University Medical School, Osaka, Japan

    Kyoko Takahashi, Hisato Harada & Junichi Azuma

  2. Department of Pharmacology, University of South Alabama School of Medicine, Mobile, AL, USA

    Stephen W. Schaffer

Authors
  1. Kyoko Takahashi
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  2. Hisato Harada
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  3. Stephen W. Schaffer
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  4. Junichi Azuma
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Editor information

Editors and Affiliations

  1. Texas Tech University Health Sciences Center, Lubbock, Texas, USA

    John B. Lombardini

  2. University of South Alabama School of Medicine, Mobile, Alabama, USA

    Stephen W. Schaffer

  3. Osaka University Medical School, Osaka, Japan

    Junichi Azuma

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© 1992 Springer Science+Business Media New York

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Takahashi, K., Harada, H., Schaffer, S.W., Azuma, J. (1992). Effect of Taurine on Intracellular Calcium Dynamics of Cultured Myocardial Cells During the Calcium Paradox. In: Lombardini, J.B., Schaffer, S.W., Azuma, J. (eds) Taurine. Advances in Experimental Medicine and Biology, vol 315. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3436-5_17

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  • DOI: https://doi.org/10.1007/978-1-4615-3436-5_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6520-4

  • Online ISBN: 978-1-4615-3436-5

  • eBook Packages: Springer Book Archive

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