Abstract
The Multi-institutional Osteosarcoma Study (MIOS) was initiated in June 1982 and was designed to test the role of adjuvant chemotherapy in the treatment of osteosarcoma of the extremity. At the time of initiation of this trial, the role of adjuvant chemotherapy in the treatment of osteosarcoma was controversial, because the outcome of patients treated with only surgery and without adjuvant chemotherapy appeared to be improving over time at certain institutions [1,2]. Preliminary [3] and updated [4] results of this trial have been published and have confirmed the favorable impact of adjuvant chemotherapy on event-free survival for patients with osteosarcoma of the extremity; the outcome for patients treated with immediate adjuvant chemotherapy was significantly better than for those treated with only surgery.
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References
Taylor WF, Ivins JC, Dahlin DC, et al. Trends and variability in survival from osteosarcoma. Mayo Clinic Proc 53:695–700, 1978.
Edmonson J, Green S, Ivins J, et al. A controlled pilot study of high-dose methotrexate as post surgical adjuvant treatment for primary osteosarcoma. J Clin Oncol 2;152–156, 1984.
Link MP, Goorin AM, Miser AW, et al. The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity. N Engl J Med 314:1600–1606, 1986.
Link MP, Shuster JJ, Goorin A, et al. Adjuvant chemotherapy in the treatment of osteosarcoma: Results of the Multi-Institutional Osteosarcoma Study. In: Recent Concepts in Sarcoma Treatment. Ryan JR Baker LO, Eds. Kluwer Academic, Dordrecht, The Netherlands, 1988, pp 283–290.
Eilber F, Giuliano A, Eckardt J, et al. Adjuvant chemotherapy for osteosarcoma: A randomized prospective trial. J Clin Oncol 5:21–26, 1987.
Winkler K, Beron G, Kotz R, et al. Neoadjuvant chemotherapy for osteogenic sarcoma: results of a cooperative German/Austrian Study. J Clin Oncol 2:617–624, 1984.
Provisor A, Nachman J, Krailo M, et al. Treatment of non-metastatic osteosarcoma of the extremities with pre-and post-operative chemotherapy. Proc Am Soc Clin Oncol 6:217, 1987.
Winkler K, Beron G, Delling G, et al. Neoadjuvant chemotherapy of osteosarcoma: results of a randomized cooperative trial (COSS-82) with salvage chemotherapy based on histological tumor response. J Clin Oncol 6:329–337, 1988.
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© 1993 Springer Science+Business Media New York
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Link, M.P. (1993). The multi-institutional osteosarcoma study: An update. In: Humphrey, G.B., Koops, H.S., Molenaar, W.M., Postma, A. (eds) Osteosarcoma in Adolescents and Young Adults: New Developments and Controversies. Cancer Treatment and Research, vol 62. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3518-8_31
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DOI: https://doi.org/10.1007/978-1-4615-3518-8_31
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