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The cell cycle in protozoan parasites

  • Chapter
Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

Research into cell cycle control in protozoan parasites, which are responsible for major public health problems in the developing world, has been hampered by the difficulties in performing classical genetic analysis with these organisms. Nevertheless, in a large part thanks to the data gathered in other eukaryotic systems and to the acquisition of the sequences of parasite genes homologous to cell cycle regulators, many molecular tools required for an in-depth study of the cell cycle in protozoan parasites have been collected over the past few years. Despite the considerable phylogenetic divergence between these organisms and other eukaryotes, and notwithstanding important specificities such as the apparent lack of checkpoints during cell cycle progression, available data indicate that the major families of cell cycle regulators appear to operate in protozoan parasites. Functional studies are now needed to define the precise role of these regulators in the life cycle of the parasites, and to possibly validate cell cycle control elements as potential targets for chemotherapy.

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Author information

Authors and Affiliations

  1. Immunobiologie moléculaire et cellulaire des maladies parasitaires, INSERM U313, 91 Boulevard de l’Hôpital, F-75634, Paris, France

    Christian Doerig

  2. Department of Molecular Biology and Microbiology, University of Central Florida, Orlando, FL, 32816, USA

    Debopam Chakrabarti

  3. Biochemie-Zentrum, Ruprecht-Karls-Universität, D-69120, Heidelberg, Germany

    Barbara Kappes

  4. School of Biological Sciences, 214 Stopford Building, University of Manchester, Oxford Road, Manchester, UK

    Keith Matthews

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  1. Christian Doerig
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  2. Debopam Chakrabarti
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  3. Barbara Kappes
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  4. Keith Matthews
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Editors and Affiliations

  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer  & Armelle Jézéquel  & 

  2. Centre National de la Recherche Scientifique, Université Paul Sabatier, Toulouse, France

    Bernard Ducommun

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Doerig, C., Chakrabarti, D., Kappes, B., Matthews, K. (2000). The cell cycle in protozoan parasites. In: Meijer, L., Jézéquel, A., Ducommun, B. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4253-7_15

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