Abstract
The purpose of the urinary bladder is to store urine at low pressures, and allow for effective evacuation at an appropriate time, location and social situation. For this complex set of requirements to be carried out, it is essential that the major components of the lower urinary tract interact in a unified fashion.1 The basic elements of the bladder which contribute to the active (contractile) and passive properties (resistance to deformation) are listed in Table 1. It is important to note that even the passive properties of the urinary bladder are in part determined by actin myosin interactions that are calcium mediated and energy dependent. Failure of any one (usually several) of these components will contribute to a failure to empty or to store, or some combination thereof. Although each component within this table makes an important contribution to shaping the bladder’s biologic properties, the purpose of this review will be to focus on the role of cell calcium regulation in which the sarcoplasmic reticulum (SR) plays a major role.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Zderic, S.A., Wein, A.J., Levin, R.M.: Voiding Function: Relevant anatomy, physiology, pharmacology, and molecular aspects, in: Gillenwater, J., Grayhack, J., Howards, S., Duckett, J. (eds). Adult and Pediatric Urology. 3rd Edition, Year Book, 1995, Chicago, pages 1159.
Zderic, S.A.,: Bladder smooth muscle: stimuli for growth, in Bladder Development and Function. Cheng, E.Y. (ed), Dialogues in Ped. Urology 20 (9): 3,1997.
Langer, G.: Calcium and the heart: exchange at the tissue, cell, and organelle levels. FASEB Journal, 6: 893,1992.
Maclennan, D.: Purification and properties of an adenosine triphosphatase from sarcoplasmic reticulum. J. Biol. Chem. 245: 4508, 1970.
Jorgenson, A.D., Arnold, W., Pepper, D.R., Kahl, S.D., Mandel, F., Campbell, K.P.: A monoclonal antibody to the Ca-ATPase of cardiac sarcoplasmic reticulum cross reacts with slow type I but not with fast type II canine skeletal muscle fibers on immunocytochemical and immunochemical study. J. Cell Motil. Cytoskel. 9: 164, 1988.
Lytton, J., Zarian-Herzog, A., Periasamy, M., Maclennan, D.H.: Molecular cloning of the mammalian smooth muscle sarco(endo)plasmic reticulum Ca++Mg++ ATPase. J. Biol. Chem. 264: 7059, 1989.
Carafoli, E.: Biogenesis: Plasma membrane calcium ATPase: 15 years of work on the purified enzyme. FASEB J., 8: 993, 1994.
Khan, I., Grover, A.K.: Expression of cyclic nucleotide sensitive and insensitive isoforms of the plasma membrane Ca2+ pump in smooth muscle and other tissues. Biochem. Journal 277: 345,1991.
Ishida, Y., Riesinger, I., Wallimann, T., Paul, R.J.: Compartmentation of ATP synthesis and utilization in smooth muscle: roles of aerobic glycolysis and creatine kinase. Molecular and Cellular Biochemistry 133/134: 39,1994.
Book, C.S., Moore, R.L., Semanchik, A., Ng, Y,C.: Cardiac hypertrophy alters expression of Na+k+ATPase subunit isoform levels at mRNA and protein levels in rat myocardium. J. Mol. Cell. Cardiol. 26: 591,1994.
Madsen, K., Franch, J., Clausen, T.: Effects of intensified endurance training on the concentration of the Na+K+ATPase and Ca++ATPase in human skeletal muscle. Acta Physiol. Scand. 50: 251,1994.
Volpe, P., Martini, A., Furlan, S., Melodesi, J.: Calsequestrin is a component of smooth muscles; the skeletal and cardiac muscle isoforms are both present, although in highly variable amounts and ratios. Biochem. Journal 201: 465,1994.
Zderic, S.A., Gong, C., Sillen, U., Liu, G.H., Duckett, J.W., Snyder, H.M., Levin, R.M.: Developmental aspects of excitation contraction coupling in rabbit bladder smooth muscle. J. Urol. 152: 679, 1994.
Gong, C., Zderic, S.A., Levin, R.M.: Ontogeny of the ryanodine receptor in rabbit bladder smooth muscle. Mol. & Cellular Biochem 137: 169, 1994.
Nixon, G.F., Migerny, G.A., Somlyo, A.V.: Immunogold localization of inositol 1,4,5-triphosphate receptors and characterization of ultrastructural features of the sarcoplasmic reticulum in phasic and tonic smooth muscle. J. Muscle Research and Cell Motility 15: 682,1994.
Franzini-Armostrong, C.: Utrastructural studies on feet/ryanodine receptors. In: Ryanodine Receptors, Sorrentino, V. (ed), CRC Press, Orlando, 1995, pages 1–6.
Raymaekers, L., Wuytack, F.: Calcium pumps in smooth muscle cells. J. Muscle Research and Cell Motility, 14: 141, 1993.
Van Breeman, C., Chen, Q., Laher, I.: Superficial buffer barrier function of smooth muscle sarcoplasmic reticulum. Trends in Pharm. Sci. 16(3): 98,1995.
Fry, C.H., Wu, C.: Initiation of contraction in detrusor smooth muscle. Scand. J. Urol. & Nephrol. 184: 7,1997.
Aksoy, M.O., Mras, S., Kamm, K.E., Murphy, R.A.: Calcium, cAMP, and changes in myosin phosphorylation during contraction of smooth muscle. Am. J. Physiol. 245: C255, 1983.
DiSalvo, J., Nelson, S.R., Kaplan, N.: Protein tyrosine phosphorylation in smooth muscle: a potential coupling mechanism between receptor activation and intracellular calcium. Proc. Society Exptl. Med. Biol. 214: 285,1997.
Gerthoffer, W.T.: Dissociation of myosin phosphorylation and active tension during muscarinic stimulation of tracheal smooth muscle. J. Pharm. Exptl Ther. 240: 8, 1987.
Gerthoffer, W.T.: Regulation of the contractile element of airway smooth muscle. Am. J. Physiol. 261: L15, 1992.
Studer, R., Reinecke, H., Bilger, J., Exchenhagen, T., Bohm, M., Hassenfuss, et al: Gene expression of the cardiac Na+Ca++ exchanger in end stage human heart failure. Circ. Res. 75: 443, 1994.
Rabinowitz, R., Peters, M.T., Vyas, S., Campbell, S., Nicolaides, K.H.: Measurement of fetal urine production in normal pregnancy by real time ultrasonography. Am. J. Obs. & Gyn. 161: 1262, 1989.
Kirsch, A.J., Quinn, M.T., Zderic, S.A., et al: Bladder and renal effects of partial urethral obstruction in the fetal lamb. J. Urol.: submitted, 1998.
Koo, H.P., Macarak, E.J., Zderic, S.A., Duckett, J.W., Snyder, H.M., Levin, R.M.: The ontogeny of bladder function in the fetal calf. J. Urol. 154: 283,1995.
Klitzner, T.S., Friedman, W.F.: A diminished role of sarcoplasmic reticulum in newborn myocardial contraction: the effects of ryanodine. Ped. Res., 26: 98, 1989.
Fisher, D., Tate, C., Phillips, S.: Developmental regulation of the sarcoplasmic reticulum calcium pump in the rabbit heart. Ped. Res., 31: 474, 1992.
Zderic, S.A, Sillen, U., Liu, G., Snyder, H.M., Duckett, J.W., Wein, A.J., Levin, R.M.: Developmental aspects of bladder contractile function: evidence for an intracellular calcium pool. J. Urol. 150: 623, 1993.
Thastrup, O., Dawson, A.P., Scharff, O., Foder, B, et al: Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage. Agents and Actions 27: 17, 1989.
Lytton, J., Westlin, M., Hanley, M.R.: Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps. J. Biol. Chem. 266: 17067.
Graham, E.G., Mishra, O.P., Delivoria-Papadopoulos, M. (1993), Brain cell Na+K+ATPase modificiation following hypoxia in the guinea pig fetus. Neuroscience Letters, 153: 93.
Zderic, S.A., Gong, C.: Developmental regulation of the Ca2+Mg2+ATPase of the the sarcoplasmic reticulum of rabbit urinary bladder smooth muscle. Mol. & Cell. Biochem.: submitted, 1998.
Khan, I., Grover, A.K.: Cloning of internal Ca pump from rabbit stomach smooth muscle. Nucleic Acids res. 18: 4026,1990.
Mearow, K.M., Thilander, B.G., Khan, I., Garfield, R.E., Grover, A.K.: In situ hybridization and immuno-cytochemical localization of SERCA2 encoded Ca2+ pump in rabbit heart and stomach. Mol. & Cell. Biochm. 121: 155,1993.
Zderic, S.A., Wein, A.J., Rohrnmann, D., Gong, C., Nigro, D., Haugaard, N., Levin, R.M.: Mechanisms of bladder smooth muscle hypertrophy and decompensation: lessons from normal development and the response to outlet obstruction. World J. Urol. 1998, in press.
Zderic, S.A., Rohrmann, D., Gong, C., Snyder, H.M., Duckett, J.W., Wein, A.J., Levin, R.M.: The decompensated detrusor II: evidence for loss of sarcoplasmic reticulum following bladder outlet obstruction in the rabbit. J. Urol. 156: 587, 1996.
Sullivan, M.P., Yalla, S.V.: Detrusor contractility and compliance characteristics in adult male patients with obstructive and non obstructive voiding patterns. J. Urol. 155: 1995, 1996.
Djavan, B., Madersbacher, S., Klingler, C., Marberger, M.: Urodynamic assessment of patients with acute urinary retention: is treatment failure after prostactectomy predictable? J. Urol. 158: 1829,1997.
O’Connor, L.T., Vaughan, E.D., Felsen, D.: In vivo cystometric evaluation of progressive bladder outlet obstruction in rats. J. Urol. 158: 631,1997.
Arai, M., Matsui, H., Periasamy, M.: Sarcoplasmic reticulum gene expression in cardiac hypertrophy and heart failure. Circ. Res. 74: 555, 1995.
Komuro, I., Kurabayashi, M., Shibazaki, Y., Takaku, F., Yazaki, Y.: Molecular cloning and characterization of a Ca Mg dependent ATP ase from rat cardiac sarcoplasmic reticulum. Regulation of its expression by pressure overload and developmental stage. J. Clin. Invest. 83: 1102,1989.
Feldman, A.M., Weinberg, E.O., Ray, P.E., Lorell, B.H.: Selective changes in cardiac gene expression during compensated hypertrophy and the transition to cardiac decompensation in rats with chronic aortic banding. Circ. Res. 73: 184, 1993.
Briggs, F.N., Lee, K.F., Feher, J.F., Wechsler, A.S., Ohlendieck, K., Campbell, K.: Ca-ATPase isozyme expression is altered by chronic stimulation of skeletal muscles. FEBS Letters 259: 269,1990.
Schulte, L.M., Navarro, J., Kandarian, S.C.: Regulation of sarcoplasmic reticulum gene expression by hind limb unweighting. Am. J. Phys. 264: C1308, 1993.
Grover, A.K., Samson, S.E., Fomin, V.P., Werstiuk, E.S.: Effects of peroxide and superoxide on coronary artery: ANGII response and sarcoplasmic reticulum Ca2+ pump. Am. J. Physiol. 269: C546,1995.
Yoshida, K., Inui, M., Harada, K., Saido, T.C., Sorimachi, Y., Ishihara, T., Kawashama, S., Sobue, K.: Reperfusion of rat heart after brief ischemia induces proteolysis of calspectin by calpain. Circ. Res. 77: 603,1995.
Levin, R.M., Goldman, M., Wein, A.J.: Effect of isoproterenol and EGTA on the volume pressure relationship of the in vitro whole bladder preparation. Neurourology & Urodynamics 3: 133,1984.
Copien, D., Macarak, E.J., Levin, R.M.: Developmental changes in fetal bovine whole bladder physiology. J. Urol. 151: 1391,1994.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer Science+Business Media New York
About this chapter
Cite this chapter
Zderic, S.A. et al. (1999). Calcium Ion Homeostasis in Urinary Bladder Smooth Muscle. In: Baskin, L.S., Hayward, S.W. (eds) Advances in Bladder Research. Advances in Experimental Medicine and Biology, vol 462. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4737-2_12
Download citation
DOI: https://doi.org/10.1007/978-1-4615-4737-2_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7147-2
Online ISBN: 978-1-4615-4737-2
eBook Packages: Springer Book Archive