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Carotid Chemoreflex

Neural Pathways and Transmitters

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Frontiers in Arterial Chemoreception

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 410))

Abstract

Relatively little is known regarding the neural pathways mediating the respiratory responses to chemoreceptor stimulation and the transmitters involved in these pathways. Recently published information on this topic is presented in this short review.

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References

  • Bianchi AL, Denavit-Saubie M & Champagnat J (1995) Central control of breathing in mammals: neuronal circuitry, membrane properties, and neurotransmitters. Physiol Rev 75: 1–45

    PubMed  CAS  Google Scholar 

  • Bonham A (1995) Neurotransmitters in the CNS control of breathing. Respir Physiol 101: 219–230

    Article  PubMed  CAS  Google Scholar 

  • Chitravanshi VC, Kachroo A & Sapru HN (1994) A midline area in the nucleus commissuralis of NTS mediates the phrenic nerve responses to carotid chemoreceptor stimulation. Brain Res 662: 127–133

    Article  PubMed  CAS  Google Scholar 

  • Chitravanshi VC & Sapru HN (1995a) Chemoreceptor-sensitive neurons in commissural subnucleus of nucleus tractus solitarius of the rat. Am J Physiol 268: R851–R858.

    PubMed  CAS  Google Scholar 

  • Chitravanshi VC & Sapru HN (1995b) NMDA as well as non-NMDA receptors in the phrenic motor nucleus mediate respiratory effects of carotid chemoreflex. Soc Neurosci Abstr 21: 642

    Google Scholar 

  • Claps A & Torrealba F (1988) Carotid body connections: A WGA-HRP study in the cat. Brain Res 455: 123–133

    Article  PubMed  CAS  Google Scholar 

  • Davies RO & Edwards Jr MW (1975) Medullary relay neurons in the carotid body chemoreceptor pathways of cats. Respir Physiol 24: 69–79

    Article  PubMed  CAS  Google Scholar 

  • Ellenberger HH & Feldman JL (1988) Monosynaptic transmission of respiratory drive to phrenic motoneurons from brainstem bulbospinal neurons in rats. J Comp Neurol 269: 47–57

    Article  PubMed  CAS  Google Scholar 

  • Finley JCW & Katz DM (1992) The central organization of carotid body afferent projections to the brainstem of the rat. Brain Res 572: 108–116

    Article  PubMed  CAS  Google Scholar 

  • Greer JJ, Smith JC & Feldman JL (1991) Role of excitatory amino acids in the generation and transmission of respiratory drive in neonatal rat. J Physiol, London 437: 727–749

    CAS  Google Scholar 

  • Guyenet PG & Koshiya N (1995) Working model of the sympathetic chemoreflex in rats. Clin Exp Hypertens 17: 167–179

    Article  PubMed  CAS  Google Scholar 

  • Jordan D (1994) Central integration of chemoreceptor afferent activity. In: O’Regan RG, Nolan P, McQueen DS & Paterson DJ (eds) Arterial Chemoreeeptors: Cell to System. New York: Plenum Press. pp 87–98

    Google Scholar 

  • Lipski J, McAllen RM & Spyer KM (1977) The carotid chemoreceptor input to the respiratory neurons of the nucleus of tractus solitarius. J Physiol, London 269: 797–810

    CAS  Google Scholar 

  • Liu G, Feldman JL & Smith J (1990) Excitatory amino acid-mediated transmission of inspiratory drive to phrenic motoneurons. J Neurophysiol 64: 423–436

    PubMed  CAS  Google Scholar 

  • McCrimmon DR, Smith J. & Feldman, JL (1989) Involvement of excitatory amino acids in neurotransmission of inspiratory drive to spinal respiratory motoneurons. J Neurosci 9: 1916–1921

    Google Scholar 

  • Sapru HN & Krieger AJ (1977) Carotid and aortic chemoreceptor function in the rat. J Appl Physiol 42: 344–348

    PubMed  CAS  Google Scholar 

  • Sapru HN, Gonzalez ER & Krieger AJ (1981a) Aortic nerve stimulation in the rat: cardiovascular and respiratory responses. Brain Res Bull 6: 393–398

    Article  PubMed  CAS  Google Scholar 

  • Sapru HN, Willette RN & Krieger AJ (1981b) Stimulation of pulmonary J receptors by an enkephalin-analog. J Pharmacol Exp Ther 217: 228–234

    PubMed  CAS  Google Scholar 

  • Sundaram K, Murugaian J, Watson M & Sapru HN (1989) M2 muscarinic receptor agonists produce hypotension and bradycardia when injected into the nucleus tractus solitarius. Brain Res 477: 358–362

    Article  PubMed  CAS  Google Scholar 

  • Urbanski RW & Sapru HN (1988) Putative neurotransmitters involved in medullary cardiovascular regulation. J Auton Nerv Syst 25: 181–193

    Article  PubMed  CAS  Google Scholar 

  • Vardhan A, Kachroo A, Sapru HN (1993) Excitatory amino acid receptors in commissural nucleus of the NTS mediate carotid chemoreceptor responses. Am J Physiol 264: R41–R50

    PubMed  CAS  Google Scholar 

  • Willette RN, Barcas PP, Krieger AJ & Sapru HN (1984) Vasopressor and depressor areas in the rat medulla: identification by microinjection of L-glutamate. Neuropharmacology 22: 1071–1079

    Article  Google Scholar 

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© 1996 Springer Science+Business Media New York

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Sapru, H.N. (1996). Carotid Chemoreflex. In: Zapata, P., Eyzaguirre, C., Torrance, R.W. (eds) Frontiers in Arterial Chemoreception. Advances in Experimental Medicine and Biology, vol 410. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5891-0_55

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  • DOI: https://doi.org/10.1007/978-1-4615-5891-0_55

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7702-3

  • Online ISBN: 978-1-4615-5891-0

  • eBook Packages: Springer Book Archive

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