Abstract
Hyperuricemia and gout have been reported in patients receiving cyclosporin therapy for immunosuppression after organ transplantation.1–5 We evaluated the frequency and mechanism of hyperuricemia during cyclosporine A therapy in a group of patients who had received a renal transplant.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
D.J. Tiller, B.M. Hall, J.S. Hovrarth, G.G. Duggin, J.F. Thompson, and A.G. Sheil, Gout and hyperuricemia in patients on cyclosporin and diuretics, Lancet 1: 453 (1985).
A.G. Palestine, R.B. Nussenblat, and C.C. Chan, Side effects of systemic cyclosporin in patients not undergoing transplantation, Am. J. Med. 77: 652 (1984).
J.R. Chapman, D. Griffiths, N.G. Harding, and P.J. Morris, Reversibility of cyclosporin nephrotoxicity after three month’s treatment, Lancet 1: 128 (1985).
J.P. VanHooff, K.M.L. Leunissen, and W. vandeStaak, Cyclosporin, uric acid, and the kidney, Lancet 1: 701 (1985).
J.S. Najarian, D.S. Fryd, M. Strand, D.M. Canafax, N.L. Ascher, W.D. Payne, R.L. Simmons, and D.E. Futherland, A single institution randomized prospective trial of cyclosporin versus azathioprine — antilymphocyte globulin for immunosuppression in renal allograft recipients, Ann. Sura. 201: 142 (1985).
N.L. Edwards, D. Recker, D. Airozo, and I.H. Fox, Enhanced purine salvage during allopurine therapy: an important pharmacologie property in humans, J. Lab. Clin. Med. 98: 673–683 (1981).
Z. Targhese, M.K. Chan, L.V. Steele, P. Sweny, O.N. Fernando, and J.F. Moorhead, How to measure cyclosporin, Lancet 1: 1407 (1984).
R. Bianchi, C. Vitali, A. Clerico, A. Pilo, L. Riente, L. Fusani, and G. Mariani, Uric acid metabolism in normal subjects and in gouty patients by Chromatographic measurementof 14C-uric acid in plasma and urine, Metabolism (1979).
B.M. Hall, D.J. Tiller, I. Hardie, J. Mahony, T. Mathew, G. Thatcher, P. Miach, N. Thomson, and A.G. RossSheil, Comparison of three immunosuppressive regimens in cadaver renal transplantation: long-term cyclosporin, short-term cyclosporine followed by azathioprine and prednisolone, and azathioprine and prednisone withou;cyclosporine, N. Enal. J. Med. 318: 1499 (1988).
B.D. Kahan, S.M. Flechner, M.I. Lorber, D. Golden, S. Conley, and C.T. Van Buren, Complication of cyclosporine-prednisone immunosuppression in 402 renal allograft recipients exclusively followed at a single center from one to five years, Transplantation 43: 197 (1987).
S.L. Cohen, G. Boner, J.B. Rosenfeld, D. Shmuel, O. Sperling, A. Yusim, A. Todd-Pokropek, and Z. Shapira, The mechanism of hyperuricemia in cyclosporin-treated renal transplant recipients, Transplant Proc. 1829 (1987).
C. West, B.J. Carpenter, and T.R. Hakala. The incidence of gout in renal transplant recipients, Am. J. Kid. Dis. 10: 369 (1987).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Plenum Press, New York
About this chapter
Cite this chapter
Lin, HY., Rocher, L.L., McQuillan, M.A., Palella, T.D., Fox, I.H. (1989). Hyperuricemia and Gout in Cyclosporin A-Treated Renal Transplant Recipients. In: Mikanagi, K., Nishioka, K., Kelley, W.N. (eds) Purine and Pyrimidine Metabolism in Man VI. Advances in Experimental Medicine and Biology, vol 253A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5673-8_48
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5673-8_48
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5675-2
Online ISBN: 978-1-4684-5673-8
eBook Packages: Springer Book Archive