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Acetylcholine Induced Antinociception: Comparisons to Opiate Analgesia

  • Chapter
Cholinergic Mechanisms

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 25))

Abstract

The ability of a number of cholinomimetic drugs to inhibit nociceptive responses in several animal species is well documented. Cholinomimetic agents which have shown antinociceptive activity in a variety of tests include the following: oxotremorine (16,19,26,32, 37,38,42), tremorine (7), arecoline (23,25,29,37,44), pilocarpine (10,25,29) and physostigmine (10,20,22,28,34,42,44,49). The specific central muscarinic mediation of these antinociceptive effects is agreed upon by most authors (10,25,28,37). Cholinomimetic drugs also potentiate narcotic analgesia in laboratory animals (1,26,28, 29,42,46,56) and in man (8,15,40,50,54). However, the relationship of cholinomimetic to narcotic analgesia remains unclear. Both classes of drugs demonstrate antinociceptive activity in similar tests and tolerance to each has been noted (see 48,55; also 10,26, 34). Significant cross-tolerance between narcotics and cholinomimetics has not been observed. Investigations into the possible inhibition of cholinergic antinociception by narcotic antagonists (7,18,20,26-28,42) and, conversely, the inhibition of narcotic analgesia by muscarinic receptor blockers (3,7,8,10,27-29,56) have yielded mixed results.

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Louisiana State University Medical School, New Orleans, Louisiana, 70119, USA

    N. W. Pedigo & W. L. Dewey

  2. Department of Pharmacology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, 23298, USA

    W. L. Dewey

Authors
  1. N. W. Pedigo
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  2. W. L. Dewey
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Editor information

Editors and Affiliations

  1. Institute of Pharmacology, University of Florence, Florence, Italy

    Giancarlo Pepeu

  2. Mario Negri Institute for Pharmacological Research, Milan, Italy

    Herbert Ladinsky

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© 1981 Plenum Press, New York

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Pedigo, N.W., Dewey, W.L. (1981). Acetylcholine Induced Antinociception: Comparisons to Opiate Analgesia. In: Pepeu, G., Ladinsky, H. (eds) Cholinergic Mechanisms. Advances in Behavioral Biology, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8643-8_78

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  • DOI: https://doi.org/10.1007/978-1-4684-8643-8_78

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8645-2

  • Online ISBN: 978-1-4684-8643-8

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