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Role of Platelet-Derived Growth Factor in Vivo

  • Chapter
The Molecular and Cellular Biology of Wound Repair

Abstract

Platelet-derived growth factor (PDGF) was originally identified as a mitogen for fibroblasts, smooth muscle cells, and glial cells (Kohler and Lipton, 1974; Ross et al., 1974; Westermark and Wasteson, 1976). PDGF was subsequently purified from human platelets (Antoniades et al., 1979; Deuel et al., 1981; Heldin et al., 1979; Raines and Ross, 1982). More recent studies have shown that PDGF is synthesized by a number of cell types and also acts on many different cell types (for reviews on PDGF, see Heldin and Westermark, 1990; Raines et al., 1990).

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  1. Ludwig Institute for Cancer Research, Biomedical Center, S-751 24, Uppsala, Sweden

    Carl-Henrik Heldin

  2. Department of Pathology, University Hospital, S-751 85, Uppsala, Sweden

    Bengt Westermark

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  1. Carl-Henrik Heldin
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  1. Department of Dermatology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York, 11794-8165, USA

    Richard A. F. Clark

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Heldin, CH., Westermark, B. (1988). Role of Platelet-Derived Growth Factor in Vivo . In: Clark, R.A.F. (eds) The Molecular and Cellular Biology of Wound Repair. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0185-9_7

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  • DOI: https://doi.org/10.1007/978-1-4899-0185-9_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0187-3

  • Online ISBN: 978-1-4899-0185-9

  • eBook Packages: Springer Book Archive

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