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Immunopathogenesis of Kaposi’s Sarcoma

  • Chapter
Immunology of HIV Infection

Abstract

Kaposi’s sarcoma (KS) is a proliferative disease of vascular origin and is the most frequent tumor of human immunodeficiency virus type 1 (HIV-1)-infected individuals, particularly of homosexual and bisexual men (Friedman-Kien et al., 1981; Havercos et al., 1985; Safai et al., 1985). In patients with acquired immunodeficiency syndrome (AIDS), KS (AIDS-KS) generally has an aggressive and rapid course that is characterized by widely distributed skin lesions, and early dissemination to visceral organs (Safai et al., 1985; Gottlieb and Ackerman, 1982). Other clinical types of KS include classical KS, an indolent disease that affects the lower extremities of elderly men of Mediterranean origin. Iatrogenic KS occurs in 5% of recipients of solid organ transplants, especially those taking glucocorticoids for immune suppression. Endemic KS occurs primarily in men of sub-Saharan Africa origin (Taylor et al., 1972; Slavin et al., 1969).

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  1. Institute of Human Virology, Medical Biotechnology Center, University of Maryland, Baltimore, Maryland, 21201, USA

    Felipe Samaniego & Robert C. Gallo

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  1. Felipe Samaniego
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  1. University of California, Irvine, California, USA

    Sudhir Gupta M.D., Ph.D.

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Samaniego, F., Gallo, R.C. (1996). Immunopathogenesis of Kaposi’s Sarcoma. In: Gupta, S. (eds) Immunology of HIV Infection. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0191-0_22

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  • DOI: https://doi.org/10.1007/978-1-4899-0191-0_22

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