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Serotonin and Ethanol Preference

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Recent Developments in Alcoholism

Part of the book series: Recent Developments in Alcoholism ((RDIA,volume 7))

Abstract

This chapter brings together evidence indicating the involvement of serotonin (5-HT) in ethanol preference using data mainly obtained from selectively bred alcohol-preferring and alcohol-nonpreferring lines of rodents. Although several laboratories have established rodent lines that will consume large quantities of ethanol daily, only one line thus far has been established that satisfied all the criteria for an animal model of alcoholism and that would be suitable for studying the biological basis of ethanol preference. This is the P line of alcohol-preferring rats that: (1) freely consumes 5–9 g ethanol/kg body wt/day; (2) drinks sufficient alcohol to produce intoxicating blood alcohol concentrations; (3) works to obtain alcohol; (4) self-administers ethanol for its CNS pharmacological effects; and (5) develops chronic tolerance to and dependence on alcohol with free-choice drinking. Relative to the NP line of alcohol-nonpreferring rats, the P rat has lower 5-HT levels in several CNS regions, including some, such as the nucleus accumbens, hypothalamus, and frontal cortex, which are involved in the brain reward circuitry. Furthermore, both acute and chronic ethanol administration have effects on the 5-HT pathway from the dorsal raphe nucleus to the nucleus accumbens in the P rat. Pharmacological studies have demonstrated that fluoxetine, a serotonin uptake inhibitor, reduced the oral consumption or intragastric self-administration of alcohol in the P rats. In addition, administration of a 5-HT1B agonist also attenuated the oral intake of ethanol by P rats. It is hypothesized that the serotonergic pathway from the dorsal raphe nucleus to the nucleus accumbens is involved in the reinforcing actions of alcohol in the P line of rats.

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Authors and Affiliations

  1. Departments of Psychiatry and Biochemistry, The Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana, 46223, USA

    William J. McBride

  2. Department of Psychiatry, The Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana, 46223, USA

    James M. Murphy

  3. Departments of Medicine and Biochemistry, Indiana University School of Medicine, Indianapolis, Indiana, 46223, USA

    Lawrence Lumeng & Ting-Kai Li

  4. Richard L. Roudebush VA Medical Center, Indianapolis, Indiana, 46223, USA

    Lawrence Lumeng & Ting-Kai Li

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  1. William J. McBride
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  2. James M. Murphy
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  3. Lawrence Lumeng
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  4. Ting-Kai Li
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Editors and Affiliations

  1. New York University School of Medicine, New York, New York, USA

    Marc Galanter

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McBride, W.J., Murphy, J.M., Lumeng, L., Li, TK. (1989). Serotonin and Ethanol Preference. In: Galanter, M. (eds) Recent Developments in Alcoholism. Recent Developments in Alcoholism, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1678-5_10

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  • DOI: https://doi.org/10.1007/978-1-4899-1678-5_10

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