Abstract
Activins are members of the TGF (transforming growth factor)-β superfamily1. The members of the activin family are formed by the combination of the polypeptide chains α, βA and βB. The combination of β with α builds the inhibins, homo and heterodimers of the β-proteins the activins. The homology to a subunit of TGF-β is about 35–40%.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
J. Massagué, The transforming growth factor-β family, Annu. Rev. Cell. Biol. 6:597 (1990).
T. Yamashita, S. Takahashi, and E. Ogata, Expression of activin A/erythroid differentiation factor in murine bone marrow stromal cells, Blood 79: 304 (1992).
J. Barsig, S. Küsters, K. Vogt, H.-D. Vogt, G. Tiegs, and A. Wendel, Lipopolysaccharide-induced inter-leukin-10 in mice: role of endogenous tumor necrosis factor a, Eur. J. Immunol. 25: (1995)
R.M. Niising, S. Mohr, and V. Ullrich, Activin A and retinoic acid synergize in cyclooxygenase-1 and thromboxane synthase induction during differentiation of J774.1 macrophages, Eur. J. Biochem. 227:130 (1995)
H. Schweer, B. Watzer, and H.W. Seyberth, Determination of seven prostanoids in 1 ml of urine by gas chromatography-negative ion chemical ionization triple stage quadrupole mass spectrometry, J. Chromatogr. 652:221 (1994)
R.M. Niising, T. Klein, J. Pfeilschifter, and V. Ullrich. Effect of cyclic AMP and prostaglandin E2 on the induction of nitric oxide-and prostanoid-forming path in cultured rat mesangial cells, Biochem. J. 313:617 (1996)
P. Chanmugam, L. Feng, S. Liou, B.C. Jang, M. Boudreau, G. Yu, J.H. Lee, H.J. Kwon, T. Bepppu, M. Yoshida, Y. Xia, C.B. Wilson, and D. Hwang, Radiciol, a protein tyrosine kinase inhibitor, suppresses the expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide and in experimental glomerulonephritis, J. Biol. Chem. 270:5418 (1995)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media New York
About this chapter
Cite this chapter
Nüsing, R.M., Barsig, J. (1997). Inflammatory Potency of Activin A. In: Honn, K.V., Marnett, L.J., Nigam, S., Jones, R.L., Wong, P.YK. (eds) Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3. Advances in Experimental Medicine and Biology, vol 407. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1813-0_36
Download citation
DOI: https://doi.org/10.1007/978-1-4899-1813-0_36
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-1815-4
Online ISBN: 978-1-4899-1813-0
eBook Packages: Springer Book Archive