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Cell Cycle Regulation by Checkpoints

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Cell Cycle Control

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1170))

Abstract

Cell cycle checkpoints are surveillance mechanisms that monitor the order, integrity, and fidelity of the major events of the cell cycle. These include growth to the appropriate cell size, the replication and integrity of the chromosomes, and their accurate segregation at mitosis. Many of these mechanisms are ancient in origin and highly conserved, and hence have been heavily informed by studies in simple organisms such as the yeasts. Others have evolved in higher organisms, and control alternative cell fates with significant impact on tumor suppression. Here, we consider these different checkpoint pathways and the consequences of their dysfunction on cell fate.

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Acknowledgements

We thank our colleagues and collaborators for a stimulating discussion. This work was supported by NIH grants RO1-GM087326 (M.J.O.) and T32-CA078207 (K.J.B.).

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Authors and Affiliations

  1. Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA

    Kevin J. Barnum & Matthew J. O’Connell

  2. Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Kevin J. Barnum & Matthew J. O’Connell

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  1. Kevin J. Barnum
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Correspondence to Matthew J. O’Connell .

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Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA

    Eishi Noguchi

  2. Dept of Biochemistry & Molecular Biology, Drexel University College of Medicine, Philadelphia, USA

    Mariana C. Gadaleta

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Barnum, K.J., O’Connell, M.J. (2014). Cell Cycle Regulation by Checkpoints. In: Noguchi, E., Gadaleta, M. (eds) Cell Cycle Control. Methods in Molecular Biology, vol 1170. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0888-2_2

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  • DOI: https://doi.org/10.1007/978-1-4939-0888-2_2

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