Abstract
Gastric-type adenocarcinoma of the cervix (GAS) is a novel, recently described subtype of endocervical adenocarcinoma. The clinical importance of accurate diagnosis of GAS stems from the observation that it confers worse prognosis than the usual-type endocervical adenocarcinoma. There are two unique characteristics of GAS: the tumor cells contain voluminous amounts of gastric-type mucins, and the tumor pathogenesis is not related to infection with high-risk human papillomavirus types. The histopathologic diagnosis of GAS is difficult; however, it may be confirmed by demonstration of intra-cytoplasmic gastric-type mucins using immunohistochemical staining with monoclonal antibody HIK1083. A protocol for HIK1083 immunostaining is described.
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Pirog, E.C. (2015). Diagnosis of HPV-Negative, Gastric-Type Adenocarcinoma of the Endocervix. In: Keppler, D., Lin, A. (eds) Cervical Cancer. Methods in Molecular Biology, vol 1249. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2013-6_16
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DOI: https://doi.org/10.1007/978-1-4939-2013-6_16
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Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-2012-9
Online ISBN: 978-1-4939-2013-6
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