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Midline (Central) Fluid Percussion Model of Traumatic Brain Injury

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Injury Models of the Central Nervous System

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1462))

Abstract

Research models of traumatic brain injury (TBI) hold significant validity towards the human condition, with each model replicating a subset of clinical features and symptoms. After 30 years of characterization and implementation, fluid percussion injury (FPI) is firmly recognized as a clinically relevant model of TBI, encompassing concussion through severe injury. The midline variation of FPI may best represent mild and diffuse clinical brain injury, because of the acute behavioral deficits, the late onset of subtle behavioral morbidities, and the absence of gross histopathology. This chapter outlines the procedures for midline (diffuse) FPI in adult male rats and mice. With these procedures, it becomes possible to generate brain-injured laboratory animals for studies of injury-induced pathophysiology and behavioral deficits, for which rational therapeutic interventions can be implemented.

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References

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Author information

Authors and Affiliations

  1. BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, AZ, 85016, USA

    Rachel K. Rowe Ph.D., Daniel R. Griffiths & Jonathan Lifshitz Ph.D.

  2. Department of Child Health, University of Arizona College of Medicine - Phoenix, Phoenix, 85004, AZ, USA

    Rachel K. Rowe Ph.D., Daniel R. Griffiths & Jonathan Lifshitz Ph.D.

  3. Phoenix Veteran Affairs Healthcare System, Phoenix, AZ, USA

    Rachel K. Rowe Ph.D. & Jonathan Lifshitz Ph.D.

Authors
  1. Rachel K. Rowe Ph.D.
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  2. Daniel R. Griffiths
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  3. Jonathan Lifshitz Ph.D.
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Corresponding author

Correspondence to Jonathan Lifshitz Ph.D. .

Editor information

Editors and Affiliations

  1. Banyan Biomarkers, Inc., Alachua, Florida, USA

    Firas H. Kobeissy

  2. Safar Center for Resuscitation Research, University of Pittsburgh Safar Center for Resuscitation Research, Pittsburgh, Pennsylvania, USA

    C. Edward Dixon

  3. Banyan Biomarkers, Inc. , Alachua, Florida, USA

    Ronald L. Hayes

  4. Banyan Biomarkers, Inc., Alachua, Florida, USA

    Stefania Mondello

6 Appendix: Fluid Percussion Brain Injury

6 Appendix: Fluid Percussion Brain Injury

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© 2016 Springer Science+Business Media New York

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Rowe, R.K., Griffiths, D.R., Lifshitz, J. (2016). Midline (Central) Fluid Percussion Model of Traumatic Brain Injury. In: Kobeissy, F., Dixon, C., Hayes, R., Mondello, S. (eds) Injury Models of the Central Nervous System. Methods in Molecular Biology, vol 1462. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3816-2_13

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  • DOI: https://doi.org/10.1007/978-1-4939-3816-2_13

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-3814-8

  • Online ISBN: 978-1-4939-3816-2

  • eBook Packages: Springer Protocols

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