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Maternal Obesity During Pregnancy and Cardiometabolic Development in the Offspring

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Parental Obesity: Intergenerational Programming and Consequences

Part of the book series: Physiology in Health and Disease ((PIHD))

Abstract

Maternal obesity during pregnancy is a major public health problem worldwide. In Western countries, obesity prevalence rates in pregnant women are estimated to be as high as 30 %. In addition, it is estimated that in these countries approximately 40 % of women gain an excessive amount of gestational weight. An accumulating body of evidence strongly suggests a long-term impact of maternal obesity and excessive weight gain during pregnancy on adiposity and cardiometabolic related health outcomes in the offspring throughout the life course. Maternal obesity during pregnancy may lead to developmental adaptations in the offspring, predisposing to an increased risk of adverse cardiometabolic outcomes in later life. Thus far, it remains unclear whether these associations are explained by causal underlying mechanisms or reflect confounding by various family-based socio-demographic, nutritional, lifestyle-related and genetic characteristics. Further research to explore the causality, underlying mechanisms, and potential for prevention of cardiometabolic disease in future generations by reducing maternal obesity and excessive weight gain during pregnancy is needed.

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Authors and Affiliations

  1. The Generation R Study Group (Na 29-15), Erasmus University Medical Center, 2040, 3000 CA, Rotterdam, The Netherlands

    Romy Gaillard PhD & Vincent W. Jaddoe MD, PhD

  2. Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

    Romy Gaillard PhD & Vincent W. Jaddoe MD, PhD

  3. Department of Pediatrics, Erasmus University Medical Center, Rotterdam, The Netherlands

    Romy Gaillard PhD & Vincent W. Jaddoe MD, PhD

Authors
  1. Romy Gaillard PhD
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  2. Vincent W. Jaddoe MD, PhD
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Correspondence to Romy Gaillard PhD .

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Editors and Affiliations

  1. Institute of Developmental Sciences, University of Southampton, Southampton, Hampshire, United Kingdom

    Lucy R. Green

  2. Medical Center, The University of Mississippi, Jackson, Mississippi, USA

    Robert L. Hester

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© 2016 The American Physiological Society

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Gaillard, R., Jaddoe, V.W. (2016). Maternal Obesity During Pregnancy and Cardiometabolic Development in the Offspring. In: Green, L., Hester, R. (eds) Parental Obesity: Intergenerational Programming and Consequences. Physiology in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6386-7_2

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