Abstract
The Universal Protein Resource (UniProt) is a freely available comprehensive resource for protein sequence and annotation data. UniProt is a collaboration between the European Bioinformatics Institute (EMBL-EBI), the Swiss Institute of Bioinformatics (SIB), and the Protein Information Resource (PIR). Across the three institutes more than 100 people are involved through different tasks such as expert curation, software development, and support.
This chapter introduces the functionality and data provided by UniProt. It describes example use cases for which you might come to UniProt and the methods to help you achieve your goals.
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References
The UniProt Consortium (2015) UniProt: a hub for protein information. Nucleic Acids Res 43(Database issue):D204–D212. doi:10.1093/nar/gku989
Magrane M, The UniProt Consortium (2011) UniProt Knowledgebase: a hub of integrated protein data. Database (Oxford) 2011. doi:10.1093/database/bar009
Huang H, McGarvey PB, Suzek BE et al (2011) A comprehensive protein-centric ID mapping service for molecular data integration. Bioinformatics 27(8):1190–1191. doi:10.1093/bioinformatics/btr101
Magrane M, Pundir S (2015) UniProt: exploring protein sequence and functional information. http://www.ebi.ac.uk/training/online/course/uniprot-exploring-protein-sequence-and-functional. Accessed 17 Dec 2015
LadungaI (2009) Finding homologs in amino acid sequences using network BLAST searches. Current protocols in bioinformatics/editorial board, Andreas D Baxevanis[et al] Chapter 3:Unit 3.4. doi:10.1002/0471250953.bi0304s25
Sievers F, Wilm A, Dineen D et al (2011) Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega. Mol Syst Biol 7:539. doi:10.1038/msb.2011.75
Acknowledgments
This work was supported by grant U41HG007822 from the National Institutes of Health.
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Pundir, S., Martin, M.J., O’Donovan, C. (2017). UniProt Protein Knowledgebase. In: Wu, C., Arighi, C., Ross, K. (eds) Protein Bioinformatics. Methods in Molecular Biology, vol 1558. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6783-4_2
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DOI: https://doi.org/10.1007/978-1-4939-6783-4_2
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Publisher Name: Humana Press, New York, NY
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Online ISBN: 978-1-4939-6783-4
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