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IL-9: Function, Sources, and Detection

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Th9 Cells

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1585))

Abstract

IL-9 is a pleiotropic cytokine produced in different amounts by a wide variety of cells including mast cells, NKT cells, Th2, Th17, Treg, ILC2, and Th9 cells. Th9 cells are considered to be the main CD4+ T cells that produce IL-9. IL-9 exerts its effects on multiple types of cells and different tissues. To date, its main role has been found in the immune responses against parasites and pathogenesis of allergic diseases such as asthma and bronchial hyperreactivity. Additionally, it induces the proliferation of hematologic neoplasias, including Hodgkin’s lymphoma in humans. However, IL-9 also has antitumor properties in solid tumors such as melanoma. The objective of this review is to describe IL-9, its function, sources, and methods of detection.

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Authors and Affiliations

  1. Department of Rheumatology, Universidad de Antioquia, Cl. 67 #53 – 108, Medellín, Colombia

    Wilmer Gerardo Rojas-Zuleta M.D.

  2. Department of Physiology, Universidad Nacional de Colombia, Bogotá, Colombia

    Elizabeth Sanchez M.D.

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  1. Wilmer Gerardo Rojas-Zuleta M.D.
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  2. Elizabeth Sanchez M.D.
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Correspondence to Wilmer Gerardo Rojas-Zuleta M.D. .

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  1. School of Bio Science, Sir JC Bose Laboratory Complex, Indian Institute of Technology, Kharagpur, West Bengal, India

    Ritobrata Goswami

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Rojas-Zuleta, W.G., Sanchez, E. (2017). IL-9: Function, Sources, and Detection. In: Goswami, R. (eds) Th9 Cells. Methods in Molecular Biology, vol 1585. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6877-0_2

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