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MicroRNAs: Biomarkers, Diagnostics, and Therapeutics

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Bioinformatics in MicroRNA Research

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1617))

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs (21–23 nucleotides in length) that regulate gene expression at translational or posttranslational levels. The major regulatory mechanisms include translational repression or mRNA degradation (Filipowicz et al., Curr Opin Struct Biol 15:331–341, 2005).

Aberrant expression of miRNAs has been found to be associated with a variety of human diseases such as cancers/tumors, diabetes, viral infections, cardiovascular diseases, neurodegenerative diseases, and other diseases (Wang et al., J Cell Physiol 23:25–30, 2016; Lawrie, MicroRNAs in medicine, 2013). The expression of miRNAs is tissue specific and can be used to identify tumor type and its origin (Mishra and Merlino, J Clin Invest 119:2119–2123, 2009). Many investigations suggest that the miRNA-expression profiles are novel diagnostic and prognostic biomarkers for multiple human diseases. Manipulating relevant miRNA expression or function may serve as potential therapeutic strategies for different diseases.

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Authors and Affiliations

  1. Miracle Query, Incorporated, 456 W. 29th Ave., Eugene, OR, 97405, USA

    Weili Huang Ph.D.

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  1. Weili Huang Ph.D.
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Correspondence to Weili Huang Ph.D. .

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Editors and Affiliations

  1. School of Computing, University of South Alabama, Mobile, Alabama, USA

    Jingshan Huang

  2. Department of Pharmacology, University of South Alabama, Mobile, Alabama, USA

    Glen M. Borchert

  3. Department of Computer and Information Science, University of Oregon, Eugene, Oregon, USA

    Dejing Dou

  4. Department of Electrical Engineering and Computer Science, University of Kansas, Lawrence, Kansas, USA

    Jun (Luke) Huan

  5. School of Bioengineering, Qilu University of Technology, Jinan, Shandong, China

    Wenjun Lan

  6. Mitchel Cancer Institute, University of South Alabama, Mobile, Alabama, USA

    Ming Tan

  7. Department of Endocrinology, First Affiliated Hospital, Kunming Medical University, Kunming, Yunnan, China

    Bin Wu

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Huang, W. (2017). MicroRNAs: Biomarkers, Diagnostics, and Therapeutics. In: Huang, J., et al. Bioinformatics in MicroRNA Research. Methods in Molecular Biology, vol 1617. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7046-9_4

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  • DOI: https://doi.org/10.1007/978-1-4939-7046-9_4

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