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Risk Factors and Gene Expression in Esophageal Cancer

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Cancer Epidemiology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 471))

Summary

Esophageal cancer is a significant worldwide health problem because of its poor prognosis and high incidence in certain parts of the world. Tobacco smoke and alcohol consumption are significant risk factors for esophageal squamous cell carcinoma, whereas frequent gastroesophageal reflux and sub sequent inflammatory reactions play a role in causing the adenocarcinoma. Esophageal carcinogenesis involves multiple genetic alterations. A large body of knowledge has been generated regarding molecular alterations associated with esophageal carcinogenesis. These alterations include aberrant cell cycle control, DNA repair, cellular enzymes, growth factor receptors, and nuclear receptors. This chapter reviews the most frequent gene alterations and their correlation with risk factors as well as the prevention strategies in esophageal cancer.

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Acknowledgments

We thank the Department of Scientific Publications at The University of Texas M. D. Anderson Cancer Center for editing the manuscript. The original work was supported by National Cancer Institute grants R29 CA74835, R21 CA10226, and R01 CA117895 and by the Jerry and Maury Rubenstein Foundation.

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  1. Department of Clinical Cancer Prevention, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA

    Xiao-chun Xu

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  1. Xiao-chun Xu
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  1. Division of Cancer Control and Population Sciences Bethesda, Maryland, 20892, USA

    Mukesh Verma PhD

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Xu, Xc. (2009). Risk Factors and Gene Expression in Esophageal Cancer. In: Verma, M. (eds) Cancer Epidemiology. Methods in Molecular Biology, vol 471. Humana Press. https://doi.org/10.1007/978-1-59745-416-2_17

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  • DOI: https://doi.org/10.1007/978-1-59745-416-2_17

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